Nichd: service custom crispra and crisprko editr human synthetic sgrna pool libraries - non severable
Ended Purchase Order Awarded Last action
- Contract number
- 75N94025P00545
- Awardee
-
Horizon Discovery Biosciences LIMITED UEI VTAJYAZW8MN1 Part of Revvity Inc.
- Awarding agency
-
National Institute of Child Health and Human Development
National Institutes of Health, Department of Health and Human Services
- Obligated
- $43,073
Award facts
- Opportunity
-
- CRISPR activation (CRISPRa) and knockout (CRISPRko) libraries Solicitation · 75N94025Q00190 · Posted Aug 18, 2025
- Contract value 100% obligated
- $43,072.70 Current and potential, with all options
- Completion date 100% complete
- Current and potential, with all options
- NAICS code
- 541380 Testing Laboratories and Services
- PSC
- Q301 Reference Laboratory Testing
- Set-aside
- No set-aside
- Competition
- Not Competed under SAP · 1 offer Simplified Acquisition
- Pricing
- Firm Fixed Price
- Place of performance
- Bethesda, MD 20892, USA
Award details come from SAM.gov/FPDS.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Funding Only Action | -$24 | |
| Original award | $43,096 |
About this award
The National Institute of Child Health and Human Development (NICHD) awarded a $43,072.70 firm fixed-price purchase order to Horizon Discovery Biosciences LIMITED for custom CRISPR activation (CRISPRa) and CRISPR knockout (CRISPRko) synthetic single guide RNA (sgRNA) pool libraries. The award, issued on September 10, 2025, with a completion date of September 30, 2025, provides genome-wide functional genomic screening libraries to support research identifying novel phosphate transporters. The deliverables consist of two custom reagent kits: an SLC CRISPRa synthetic sgRNA SMARTpool (Part No. LP_193551) with 452 wells across 2 plates and a CRISPRko synthetic sgRNA pool (Part No. LP_193555) with 455 wells across 2 plates, both formatted in Echo 384 horizontal plate configurations compatible with high-throughput screening protocols. The libraries provide genome-wide coverage targeting nearly all human protein-coding genes with multiple validated sgRNAs per gene in pooled lentiviral formats.
This procurement was awarded without a small business set-aside designation under Simplified Acquisition Procedures and does not involve subcontractors. Horizon Discovery Biosciences LIMITED, a Cambridge, United Kingdom-based subsidiary of Revvity Inc., specializes in manufacturing advanced genomic research tools and has established a track record of providing sophisticated genetic research materials to NIH agencies. Performance will occur at the NIH campus in Bethesda, Maryland, supporting the NICHD's ongoing genomic research initiatives. The award represents a sole-source procurement based on the requirement for specific, standardized library formats to ensure scientific integrity and data comparability in the research program.
Quick answers
Who was awarded contract 75N94025P00545?
75N94025P00545 was awarded to Horizon Discovery Biosciences LIMITED by National Institute of Child Health and Human Development (National Institutes of Health) on September 10, 2025.
How much is contract 75N94025P00545 worth?
The government has obligated $43,073 on 75N94025P00545.
Was contract 75N94025P00545 competed?
The extent of competition for 75N94025P00545 was not competed under sap. The government received 1 offer.
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