Saastronauts are faced with several health risks during both short- and long-duration spaceflight due to the space environment. Microgravity itself seems to affect cardiovascular parameters. For…

Ended Grant For Research Awarded Last action

Contract number
NNX15AB55G
Awardee
Awarding agency
Obligated
$592,605

Award facts

Contract value 94% obligated
$632,787.77 Current and potential, with all options
Completion date 100% complete
Current and potential, with all options
NAICS code
Not on record
Set-aside
No set-aside
Competition
Full and Open Competition · 0 offers Basic Research
Pricing
Other
Place of performance
Houston, TX 77030, USA

Award details come from SAM.gov/FPDS.

Transactions

Action Obligated Date
Funding Only Action 15 -$117,212
Other Administrative Action 14 $0
Other Administrative Action 13 $0
Other Administrative Action 12 $0
Other Administrative Action 11 $0
Funding Only Action 10 -$40,183
Funding Only Action 9 $122,514
Other Administrative Action 8 $0
Funding Only Action 7 $362,786
Funding Only Action 6 $83,700
Funding Only Action 5 $0
Funding Only Action 4 $66,000
Other Administrative Action 3 $0
Funding Only Action 2 $24,479
Funding Only Action 1 $75,521
Original award $15,000
Show all 16

Description

As the agency reported it.

Saastronauts are faced with several health risks during both short- and long-duration spaceflight due to the space environment. Microgravity itself seems to affect cardiovascular parameters. For example, studies on animals (rats and rhesus monkeys) have found consistent decreases in heart rate during spaceflight. Similarly, data from 12 astronauts over 6 missions showed that heart rates of astronauts were reduced in space. These early studies demonstrate an obvious change in an easy to measure cardiovascular parameter. Although cardiovascular disease is the leading cause of death in the united states, to our knowledge, cardiovascular physiology in space has not been studied, yet. More in-depth studies are now required to shed light on how microgravity exerts changes on individual cells and tissues. We believe that subcellular effects of microgravity can be documented and we hypothesize that micrornas (MIRNAS), because of their regulatory function, will be involved. MIRNAS are now understood to be powerful modulators of biological pathways and have generated considerable excitement as next-generation therapeutic targets for a variety of diseases, including cardiovascular diseases. In this proposal, we will assess the gravitational impact on the mirna response to vascular injury and will evaluate the efficiency of vascular repair in space. This will shed light on how microgravity alters vascular remodeling and healing and could reveal currently unknown targets for potential therapeutic modulation.

Quick answers

Who was awarded contract NNX15AB55G?

NNX15AB55G was awarded to Texas Heart Institute by Shared Services Center (National Aeronautics and Space Administration) on November 1, 2014.

How much is contract NNX15AB55G worth?

The government has obligated $592,605 on NNX15AB55G. Its current value, with exercised options, is $632,788.

Was contract NNX15AB55G competed?

The extent of competition for NNX15AB55G was full and open competition. The government received 0 offers.

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