Antigen-specific CD4+ T cell priming and memory response during spaceflight: spaceflight immunosuppression is a significant obstacle to long-term human space travel. Of foremost concern is whether…

Ended Grant For Research Awarded Last action

Contract number
NNX09AH21G
Awardee
Awarding agency
Obligated
$572,632

Award facts

Contract value 100% obligated
$572,632.00 Current and potential, with all options
Completion date 100% complete
Current and potential, with all options
Funding agency
Ames Research Center National Aeronautics and Space Administration
NAICS code
Not on record
Set-aside
No set-aside
Competition
Full and Open Competition · 0 offers Basic Research
Pricing
Other
Place of performance
San Francisco, CA 94121, USA

Award details come from SAM.gov/FPDS.

Transactions

Action Obligated Date
Other Administrative Action 10 $0
Other Administrative Action 9 $0
Other Administrative Action 8 $0
Other Administrative Action 7 $0
Other Administrative Action 6 $0
Other Administrative Action 5 $0
Funding Only Action 4 $75,000
Funding Only Action 3 · Spaceflight immunosuppression is a significant obstacle to long-term human space travel. Of foremost concern is whether astronauts/cosmonauts may be able to… $194,705
Funding Only Action 2 $47,495
Funding Only Action 1 $90,000
Original award $165,432
Show all 11

Description

As the agency reported it.

Antigen-specific CD4+ T cell priming and memory response during spaceflight: spaceflight immunosuppression is a significant obstacle to long-term human space travel. Of foremost concern is whether astronauts/cosmonauts may be able to generate effective protective immune responses against infections while in spaceflight. Using an innovative mouse experimental model, we propose a set of experiments that will test 1) whether initial specific activation of T cells is intact and 2) whether memory T cell function is maintained during spaceflight. Memory T cells are the mediators of immune protection after vaccinations and whether they function properly during spaceflight will determine if pre-flight vaccinations may be useful interventions. In our experimental system, transgenic T cells specific for a model protein will be transferred into recipient mice that have implanted mini-pumps. The mini-pumps will release the model protein along with non-infectious purified bacterial cell wall components. Specific T cells stimulated under these inflammatory conditions will be similar to those activated in a bacterial infection but no infectious agents will be involved. Mini-pumps will delay T cell stimulation until after mice acclimate to spaceflight to ensure that initiation of T cell activation occurs in microgravity. Naive (previously unactivated) T cells will be transferred to determine whether responses to new immunological challenges (e.g. new infections) are intact. Previously activated T cells that will develop into memory cells will be transferred to determine whether robust secondary responses may be elicited during spaceflight. Our proposal directly addresses the research priorities of the bion-ML mission to investigate resistance to infections and acquired immune responses without using infectious agents onboard the spacecraft. Together, these proposed experiments will address some of the most pressing outstanding questions in spaceflight immunology and more clearly define the risks and potential countermeasures of spaceflight immunosuppression.

Quick answers

Who was awarded contract NNX09AH21G?

NNX09AH21G was awarded to Northern California Institute For Research And Education, Inc. by Shared Services Center (National Aeronautics and Space Administration) on April 15, 2009.

How much is contract NNX09AH21G worth?

The government has obligated $572,632 on NNX09AH21G.

Which agency awarded contract NNX09AH21G?

Shared Services Center (National Aeronautics and Space Administration) awarded NNX09AH21G, with funding from Ames Research Center (National Aeronautics and Space Administration).

Was contract NNX09AH21G competed?

The extent of competition for NNX09AH21G was full and open competition. The government received 0 offers.

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