To carry out development for a drug candidate small molecule inhibitor against chikungunya virus, an alphavirus that causes debilitating and sometimes life-threatening disease in humans.

Active Definitive Contract Awarded Last action

Contract number
75N93023C00002
Awardee
Awarding agency
Obligated
$7,422,654

Award facts

Opportunity
Contract value 54% obligated
  • $7,422,654.00 Current, with exercised options
  • $13,809,006.00 Potential, with all options
Completion date 88% complete
Current and potential, with all options
Set-aside
No set-aside
Competition
Full and Open Competition · 10 offers Negotiated Proposal / Quote
Pricing
Cost Plus Fixed Fee
Place of performance
Portland, OR 97239, USA
Legislative mandates

Award details come from SAM.gov/FPDS.

Transactions

Action Obligated Date
Exercise an Option P00006 $2,726,302
Other Administrative Action P00005 $0
Other Administrative Action P00004 $0
Other Administrative Action P00003 $0
Other Administrative Action P00002 $0
Other Administrative Action P00001 $0
Original award $4,696,352

About this award

The National Institute of Allergy and Infectious Diseases awarded a $13.8 million definitive contract to Oregon Health & Science University for development of a small molecule inhibitor against Chikungunya virus on November 1, 2022, with performance through May 31, 2027, under cost-plus-fixed-fee pricing.

The originating solicitation, posted January 4, 2022, was a Broad Agency Announcement from NIAID seeking proposals for vaccine candidates, therapeutics, and diagnostics for biodefense, antimicrobial resistant infections, and emerging infectious diseases. The specific scope targets development of a novel 2-pyrimidone (SRI-42718) as a potent inhibitor of Chikungya virus infection and disease. Place of performance is Portland, Oregon.

Service Contract Inventory reporting shows actual government-invoiced labor of $548 thousand in FY2023 (1.6 FTEs, 3,322 hours), $2.4 million in FY2024 (7.0 FTEs, 14,560 hours), and $1.4 million in FY2025 (2.6 FTEs, 5,472 hours), with derived hourly rates of $165.09/hr (FY2023), $166.45/hr (FY2024), and $253.25/hr (FY2025) reflecting an upward trend. In FY2025, Oregon Health & Science University reported 67% of contractor hours subcontracted, with five named subcontractors including Sri International, University of Alabama at Birmingham, Southern Research Institute, University of North Carolina at Chapel Hill, and University of Colorado-Denver.

Subawards

Subcontractor Amount Awarded
Element Materials Technology Santa Clara Inc. TO CARRY OUT DEVELOPMENT FOR A DRUG CANDIDATE SMALL MOLECULE INHIBITOR AGAINST CHIKUNGUNYA VIRUS, AN ALPHAVIRUS THAT CAUSES DEBILITATING AND SOMETIMES… $187,000
University Of Alabama At Birmingham TO CARRY OUT DEVELOPMENT FOR A DRUG CANDIDATE SMALL MOLECULE INHIBITOR AGAINST CHIKUNGUNYA VIRUS, AN ALPHAVIRUS THAT CAUSES DEBILITATING AND SOMETIMES… $18,000
Sri International TO CARRY OUT DEVELOPMENT FOR A DRUG CANDIDATE SMALL MOLECULE INHIBITOR AGAINST CHIKUNGUNYA VIRUS, AN ALPHAVIRUS THAT CAUSES DEBILITATING AND SOMETIMES… $390,231
Southern Research Institute TO CARRY OUT DEVELOPMENT FOR A DRUG CANDIDATE SMALL MOLECULE INHIBITOR AGAINST CHIKUNGUNYA VIRUS, AN ALPHAVIRUS THAT CAUSES DEBILITATING AND SOMETIMES… $345,915
University Of North Carolina At Chapel Hill TO CARRY OUT DEVELOPMENT FOR A DRUG CANDIDATE SMALL MOLECULE INHIBITOR AGAINST CHIKUNGUNYA VIRUS, AN ALPHAVIRUS THAT CAUSES DEBILITATING AND SOMETIMES… $811,407
The Regents Of The University Of Colorado TO CARRY OUT DEVELOPMENT FOR A DRUG CANDIDATE SMALL MOLECULE INHIBITOR AGAINST CHIKUNGUNYA VIRUS, AN ALPHAVIRUS THAT CAUSES DEBILITATING AND SOMETIMES… $447,867

Quick answers

Who was awarded contract 75N93023C00002?

75N93023C00002 was awarded to Oregon Health & Science University by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on November 1, 2022.

How much is contract 75N93023C00002 worth?

The government has obligated $7,422,654 on 75N93023C00002. Its potential value, with all options, is $13,809,006.

Was contract 75N93023C00002 competed?

The extent of competition for 75N93023C00002 was full and open competition. The government received 10 offers.

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