Immune mechanisms of protection against mycobacterium tuberculosis center (IMPAC-TB)
Active Definitive Contract Awarded Last action
- Contract number
- 75N93021C00029
- Awardee
-
Seattle Children's Hospital UEI SZ32VTCXM799
- Awarding agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $48,066,661
Award facts
- Opportunity
-
- BAANIAIDNIHAI201700104 Solicitation number
- Contract value 100% obligated
- $48,066,661.00 Current and potential, with all options
- Completion date 75% complete
-
- Current, with exercised options
- Potential, with all options
- NAICS code
- 541715 Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
- Set-aside
- No set-aside
- Competition
- Full and Open Competition · 12 offers Negotiated Proposal / Quote
- Pricing
- Cost No Fee
- Place of performance
- Seattle, WA 98101, USA
- Legislative mandates
-
- Employment Eligibility Verification (E-Verify) FAR subpart 22.18
- Service Contract Inventory FAR subpart 4.17
Award details come from SAM.gov/FPDS.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Exercise an Option | $5,912,097 | |
| Other Administrative Action | $0 | |
| Exercise an Option | $4,901,576 | |
| Funding Only Action | $2,005,983 | |
| Exercise an Option | $9,540,250 | |
| Change Order | $2,114,986 | |
| Exercise an Option | $10,840,070 | |
| Other Administrative Action | $0 | |
| Change Order | $1,473,375 | |
| Exercise an Option | $5,575,606 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Other Administrative Action | $0 | |
| Original award | $5,702,718 |
Show all 16
About this award
The National Institute of Allergy and Infectious Diseases awarded a definitive contract to Seattle Children's Hospital for the Immune Mechanisms of Protection Against Mycobacterium Tuberculosis Center (IMPAC-TB) research program on August 1, 2021, with a ceiling value of $48.066 million and an ultimate completion date of July 31, 2028.
Place of performance is Seattle, Washington. The contract is priced on a cost-no-fee basis with no set-aside designation. Work examines basic induction of innate and adaptive immunity from vaccination, including studies addressing nontuberculous mycobacteria interference, RNA vaccine delivery, prime-boost regimens including BCG pre-exposure, transcriptomic host signatures, systems biology, and durable immune memory to design and evaluate efficacious vaccine candidates against Mycobacterium tuberculosis. The research spans multiple animal models (small animal, guinea pig, non-human primate) and Phase 1 clinical trials in controlled human mycobacterial challenge models.
Subcontractors include Colorado State University (performing small animal and guinea pig vaccine studies, mouse TB models, and biosafety level-III work), University of Oxford (conducting Phase 1 clinical trials at Oxford University Hospitals NHS Foundation Trust), UK Health Security Agency (non-human primate safety and efficacy studies in guinea pig and rhesus macaque models), Fred Hutchinson Cancer Center (transcriptomic analysis and systems biology), Harvard T.H. Chan School of Public Health (systems serology analysis), Statens Serum Institut (non-human primate vaccine optimization), and Denver Research Institute (mouse TB model work with Rocky Mountain Regional VA Medical Center).
Service Contract Inventory data reflects government-invoiced labor of $22.9 million across fiscal years 2021–2025, with 25.3 FTEs and 52,576 contractor hours in FY2025 alone. Blended government-paid hourly rates rose from $105.99/hr in FY2021 to $201.07/hr in FY2025. Fifty-seven percent of FY2025 contractor hours were subcontracted out across eight named subcontractors, demonstrating a coordinating-center model for multi-institutional vaccine research consortium.
Subawards
| Subcontractor | Amount | Awarded |
|---|---|---|
| Colorado State University | $1,125,492 | |
| Statens Serum Institut | $48,554 | |
| UK Health Security Agency | $551,442 | |
| University Of Oxford | $205,272 | |
| President And Fellows Of Harvard College | $573,209 | |
| Fred Hutchinson Cancer Center | $456,623 | |
| President And Fellows Of Harvard College | $60,849 | |
| UK Health Security Agency | $1,833,576 | |
| UK Health Security Agency | $652,235 | |
| Statens Serum Institut | $67,405 | |
| University Of Oxford | $420,818 | |
| Denver Research Institute | $136,373 | |
| Colorado State University | $424,038 | |
| Fred Hutchinson Cancer Center | $237,088 | |
| Denver Research Institute | $90,740 | |
| University Of Oxford | $254,093 | |
| Colorado State University | $1,412,285 | |
| UK Health Security Agency | $199,093 | |
| UK Health Security Agency | $1,427,801 | |
| Colorado State University | $899,772 | |
| Colorado State University | $29,849 | |
| University Of Oxford | $396,302 | |
| University Of Oxford | $26,105 | |
| The General Hospital Corporation | $451,067 | |
| Colorado State University | $1,874,995 | |
| Colorado State University | $19,048 |
Show all 26
Quick answers
Who was awarded contract 75N93021C00029?
75N93021C00029 was awarded to Seattle Children's Hospital by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on August 1, 2021.
How much is contract 75N93021C00029 worth?
The government has obligated $48,066,661 on 75N93021C00029.
Was contract 75N93021C00029 competed?
The extent of competition for 75N93021C00029 was full and open competition. The government received 12 offers.
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