To advance clinical and non-clinical development of an antibiotic candidate.

Ended Definitive Contract Awarded Last action

Contract number
75N93021C00022
Awardee
Awarding agency
Obligated
$10,501,521

Award facts

Opportunity
Contract value 39% obligated
  • $10,501,521.27 Current, with exercised options
  • $27,032,719.27 Potential, with all options
Completion date 100% complete
Current and potential, with all options
Set-aside
No set-aside
Competition
Full and Open Competition · 23 offers Negotiated Proposal / Quote
Pricing
Cost Plus Fixed Fee
Place of performance
Cambridge, MA 02139, USA
Legislative mandates

Award details come from SAM.gov/FPDS.

Transactions

Action Obligated Date
Terminate for Convenience P00014 $0
Terminate for Convenience P00013 · EOI::implementing the presidents department of government efficiency cost efficiency initiative (march 19, 2025)::EOI to advance clinical and non-clinical… $0
Funding Only Action P00012 $3,424,537
Other Administrative Action P00011 $0
Other Administrative Action P00010 $0
Other Administrative Action P00009 $0
Funding Only Action P00008 $85,208
Exercise an Option P00007 $779,592
Other Administrative Action P00006 $0
Other Administrative Action P00005 $0
Funding Only Action P00004 $149,482
Exercise an Option P00003 $3,972,923
Other Administrative Action P00002 $0
Other Administrative Action P00001 $0
Original award $2,089,779
Show all 15

About this award

The National Institute of Allergy and Infectious Diseases awarded a definitive contract to Spero Therapeutics, Inc. on May 17, 2021, to advance clinical and non-clinical development of an antibiotic candidate, with a ceiling value of $27,032,719.27.

The contract carries no set-aside and is priced on a cost-plus-fixed-fee basis. Place of performance is Cambridge, MA. The originating pre-solicitation, posted December 11, 2019, sought proposals to support research and development efforts for advanced therapeutic candidates and medical countermeasures targeting infectious diseases including antibiotic-resistant bacteria, with a maximum performance period of five years. Ultimate completion date is April 4, 2025.

Service Contract Inventory reporting shows the contract has invoiced $5.2 million cumulatively through FY2025. Government-paid hourly rates rose significantly from $329.53 per hour in FY2021 to $2,731.39 per hour in FY2024, reflecting the shifting nature of work scope over the performance period. Most recent staffing (FY2025) was 0.1 FTEs with self-performed labor; no subcontractors were engaged.

Quick answers

Who was awarded contract 75N93021C00022?

75N93021C00022 was awarded to Spero Therapeutics, Inc. by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on May 17, 2021.

How much is contract 75N93021C00022 worth?

The government has obligated $10,501,521 on 75N93021C00022. Its potential value, with all options, is $27,032,719.

Was contract 75N93021C00022 competed?

The extent of competition for 75N93021C00022 was full and open competition. The government received 23 offers.

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