Large scale T cell epitope discovery

Ended Definitive Contract Awarded Last action

Contract number
75N93019C00064
Awardee
Awarding agency
Obligated
$6,317,332

Award facts

Opportunity
Contract value 100% obligated
$6,317,331.67 Current and potential, with all options
Completion date 100% complete
Current and potential, with all options
Set-aside
No set-aside
Competition
Full and Open Competition · 13 offers Negotiated Proposal / Quote
Pricing
Cost No Fee
Place of performance
Worcester, MA 01655, USA
Legislative mandates

Award details come from SAM.gov/FPDS.

Transactions

Action Obligated Date
Funding Only Action P00014 · To administratively DE-obligate unexpended and expiring fiscal year 2021 funding in accordance with 31 U.S.C. Section 1552 (a), in preparation for september 30,… -$7,831
Change Order P00013 $1,108,760
Other Administrative Action P00012 $0
Funding Only Action P00011 -$2,790
Exercise an Option P00010 $1,108,761
Exercise an Option P00009 $1,070,876
Other Administrative Action P00007 $0
Other Administrative Action P00008 $0
Funding Only Action P00006 $1,035,533
Other Administrative Action P00005 $0
Other Administrative Action P00004 $0
Exercise an Option P00003 $1,024,277
Other Administrative Action P00002 $0
Other Administrative Action P00001 $0
Original award $979,746
Show all 15

About this award

Written by GovTribe AI ·

The National Institute of Allergy and Infectious Diseases awarded a definitive contract to University Of Massachusetts Medical School for large-scale T cell epitope discovery on September 30, 2019, with a ceiling value of $6.317 million. The award carries a cost-no-fee pricing structure and an ultimate completion date of September 29, 2025. The contract is being de-obligated of unexpended fiscal year 2021 funding in accordance with 31 U.S.C. Section 1552(a) in preparation for the September 30, 2026 closing of the period of availability of these funds.

Place of performance is Worcester, Massachusetts. The originating solicitation describes identification of T cell epitopes from immunogenic pathogenic fungi—including Blastomyces dermatitidis, Histoplasma capsulatum, Coccidioides posadasii, and Cryptococcus neoformans—to support development of vaccines and diagnostic reagents. Work includes screening synthetic peptides from fungal antigens for immunogenicity in transgenic mice and humans with prior exposure to these fungi, as well as depositing characterized epitope information into the immune epitope database.

The prime subcontracts with Cincinnati University (Sponsored Research Services Division), University of Wisconsin–Madison, and University of Texas at San Antonio for epitope mapping, antigen identification, and T cell activation assays across the four fungal species. ioGenetics, LLC provides immunoinformatics analysis using its EigenBio platform to generate detailed epitope maps and rankings. University of Arizona provides patient recruitment and blood sample collection.

Under Service Contract Inventory reporting (FY2025, most recent): 2.9 FTEs invoiced across 5,979 contractor hours at a derived government-paid rate of $257.34 per hour, with 4 percent of contractor hours subcontracted. Invoiced revenue rose to $1.5 million in FY2025 from $679 thousand in FY2024.

Subawards

Subcontractor Amount Awarded
Cincinnati Univ Of LARGE SCALE T CELL EPITOPE DISCOVERY Our lab will work the group and in particular, Dr. Homan to identify epitopes from immunogenic Histoplasma capsulatum… $141,999
University Of Wisconsin System LARGE SCALE T CELL EPITOPE DISCOVERY Cellular immunity, largely regulated by CD4+ T cells, is required in control of infection with the pathogenic fungus… $138,627
Iogenetics, LLC LARGE SCALE T CELL EPITOPE DISCOVERY In support of the multi-institutional effort to characterize T cell epitopes of fungi, ioGenetics will apply its EigenBio… $54,034
The University Of Texas At San Antonio LARGE SCALE T CELL EPITOPE DISCOVERY The goal of this project is to identify T-cell epitopes of pathogenic fungi including species in the genera of Blastomyces,… $127,571
University Of Arizona LARGE SCALE T CELL EPITOPE DISCOVERY Dr. Joshua Malo and his research staff will obtain IRB and institutional approvals to recruit adult patients with primary… $193,714

Quick answers

Who was awarded contract 75N93019C00064?

75N93019C00064 was awarded to University Of Massachusetts Medical School by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on September 30, 2019.

How much is contract 75N93019C00064 worth?

The government has obligated $6,317,332 on 75N93019C00064.

Was contract 75N93019C00064 competed?

The extent of competition for 75N93019C00064 was full and open competition. The government received 13 offers.

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