Project Grant R56EY036406
- Federal Grant Award Summary Baylor College of Medicine received a $646,167 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded April 1, 2026, with a completion date of March 31, 2031. The research project investigates cellular and molecular mechanisms underlying age-related macular degeneration (AMD), the leading cause of vision loss in elderly populations. The study applies high-throughput functional genomics approaches to identify causal...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $173,016 to the Whitehead Institute for Biomedical Research under the Vision Research program (CFDA 93.867) for a project grant effective August 1, 2025, through July 31, 2027. This award supports systematic identification and mechanistic characterization of novel oxidative protective genes to prevent retinal pigment epithelium (RPE) degeneration in age-related macular degeneration (AMD). The research involves...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded the University of Rochester a $1.31 million project grant effective July 1, 2025, through April 30, 2029, to investigate the pathogenic role of secretory phospholipase A2-IIA (PLA2G2A/sPLA2-IIA) in age-related macular degeneration (AMD). The research seeks to identify novel therapeutic targets for AMD, a leading cause of adult blindness with limited treatment options. The...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded a $545,948 Project Grant to The Schepens Eye Research Institute, Inc., effective April 1, 2026, through March 31, 2030. The award funds research to advance understanding of reactive astrocytes in glaucoma pathogenesis, a leading cause of irreversible blindness worldwide. The research moves beyond traditional neurocentric approaches to examine non-neuronal cellular responses in...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded New York University School of Medicine a $673,747 Vision Research project grant (CFDA 93.867) commencing June 1, 2025, and concluding May 31, 2030, to develop advanced optical imaging technology for early detection of age-related macular degeneration (AMD). The research focuses on advancing visible-to-near-infrared spanning optical coherence tomography (OCT) to achieve half-micron axial resolution for retinal imaging,...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University $615,928 on April 15, 2026, to investigate the mechanobiology of Bruch's membrane during aging and its implications for age-related macular degeneration (AMD). The primary research products will include spatial and temporal matrisome maps of the retinal pigment epithelium (RPE)/Bruch's...
- Federal Grant Award Summary Fannin Partners LLC received a $600,032 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) with an award date of September 1, 2025 and completion target of August 31, 2026. The award funds development of SCG3 raptamers—modified single-stranded DNA (ssDNA) aptamers designed as a novel targeted therapy for wet age-related macular degeneration (AMD). The project addresses a critical clinical need, as approximately 40% of...
- Federal Grant Award Summary This National Eye Institute (NEI) Vision Research program (CFDA 93.867) Project Grant award of $574,158 to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University supports a five-year research initiative (September 1, 2025 through April 30, 2030) investigating the role of melanopsin in photoreceptor outer segment renewal. The research will produce empirical findings and mechanistic insights into how melanopsin, a photosensitive protein expressed...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded The Johns Hopkins University a $695,018 Project Grant effective August 1, 2025, through July 31, 2030, to conduct research on the regulation of retinal ganglion cell regeneration through Müller glia (MG) cell function. The award supports a five-year investigation into how MG cells function as injury-responsive stem cells to enable retinal regeneration, with the ultimate goal...
The National Eye Institute (NEI) awarded The Methodist Hospital Research Institute a $1,029,472 Project Grant under the Vision Research program (CFDA 93.867) effective May 1, 2026, with completion targeted for April 30, 2028. This research initiative will develop and validate a novel cell therapy approach to treat age-related macular degeneration (AMD), the leading cause of irreversible blindness. The primary deliverables include the creation of a sustainable mitochondrial source utilizing mesenchymal stem cells (MSCs) transfected with nuclear respiratory factor 1 (NRF1) to enhance cell-to-cell mitochondrial transfer to retinal pigment epithelium cells. The research will generate characterization data on how NRF1 transfection affects MSC transcriptional activity, mitochondrial production and trafficking, and extracellular vesicle contents through molecular and biochemical methods including transcriptomics analysis. The project will validate the therapeutic strategy through testing in two rodent models of retinal degeneration, with the goal of demonstrating that NRF1-overexpressing MSCs can provide energetic support via mitochondrial mass transfer while inducing cellular reprogramming through secreted extracellular vesicle factors to counteract late-stage dry AMD. Research findings will contribute to NEI's mission of eliminating vision loss and improving quality of life through innovative vision research conducted at the awardee's facility in Houston, Texas.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 4/28/26 |