Project Grant R01EY037307
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
- Federal Grant Award Summary Baylor College of Medicine received a $1.6 million project grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded September 30, 2025, with completion scheduled for September 29, 2028. The research investigates the molecular mechanisms governing Muller glial cell (MGC) reprogramming and proliferation through modulation of the Hippo and Wnt signaling pathways. The project aims to identify cellular and molecular strategies to...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $173,016 to the Whitehead Institute for Biomedical Research under the Vision Research program (CFDA 93.867) for a project grant effective August 1, 2025, through July 31, 2027. This award supports systematic identification and mechanistic characterization of novel oxidative protective genes to prevent retinal pigment epithelium (RPE) degeneration in age-related macular degeneration (AMD). The research involves...
- Federal Grant Award Summary Baylor College of Medicine received a $1,093,095 Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research program) effective July 1, 2025 through March 31, 2030, to investigate the role of vascular ligands and neurovascular dysfunction in glaucoma pathogenesis and to identify therapeutic targets for neuroprotection. The research leverages an innovative ligandomics technology platform to globally map cell-binding ligands with binding...
- Federal Project Grant Award Summary The National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) awarded $733,137 to the University of California, Los Angeles on September 15, 2025, to support research exploring how genetic variation influences disease progression and therapeutic response in age-related macular degeneration (AMD). The project, with completion targeted for March 31, 2030, will deliver scientific research products including refined classification of AMD...
- Federal Grant Award Summary Fannin Partners LLC received a $600,032 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective September 1, 2025 through August 31, 2026. The award funds development of SCG3 raptamers—modified single-stranded DNA aptamers designed as a novel targeted therapy for wet age-related macular degeneration (AMD). The therapeutic approach targets secretogranin III (SCG3), a newly identified angiogenesis and vascular...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University a Project Grant totaling $615,928 (awarded April 15, 2026; completion March 31, 2030) under the Vision Research program (CFDA 93.867) to conduct mechanobiological research on Bruch's membrane during aging and its implications for age-related macular degeneration (AMD). The research will generate spatial and temporal matrisome...
- Federal Grant Award Summary The National Eye Institute (NEI), administering funds under the Vision Research program (CFDA 93.867), awarded the University of Maryland, Baltimore a $249,000 Project Grant effective September 30, 2025, with completion targeted for August 31, 2028. This research project will develop and validate novel fluorescence lifetime imaging technologies to assess the retinal pigment epithelium (RPE) cell mosaic in the living human eye by characterizing intracellular pigment...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded Baylor College of Medicine a Project Grant of $120,902 under the Vision Research program (CFDA 93.867) for research on the mechanisms of axoglial interactions at the paranodal junction (PNJ). The project, which commenced on April 15, 2026 and concludes on March 31, 2028, focuses on understanding the molecular composition and functional significance of the paranodal junction—the largest intercellular junction in...
- Federal Project Grant Award Summary Award Details: The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded a $504,304 Project Grant to Tufts University School of Medicine on April 15, 2026, with a project completion date of March 31, 2031. The award supports research investigating the mechanistic basis of the gut-retina axis and its relationship to age-related macular degeneration (AMD) prevention. Research Products and Services: The project will deliver...
Baylor College of Medicine received a $646,167 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective April 1, 2026 through March 31, 2031. The award funds investigations into the cellular and molecular mechanisms underlying Age-Related Macular Degeneration (AMD), the leading cause of vision loss in elderly populations. The research applies high-throughput functional genomics approaches to identify causal variants and regulatory regions among AMD genome-wide association study (GWAS) variants, with particular focus on understanding how non-coding risk variants influence gene expression in disease-relevant tissues including the retina and retinal pigment epithelium (RPE). The project delivers research products designed to advance understanding of AMD pathogenesis and inform novel therapeutic strategies. Specifically, the award supports functional testing of AMD-GWAS variants through induced pluripotent stem cell (iPSC)-derived RPE cell lines and integration of expression quantitative trait loci (eQTL) mapping data to identify target genes and biological pathways implicated in AMD susceptibility. This research addresses a significant knowledge gap regarding the mechanisms underlying known genetic risk factors and is intended to facilitate the identification of personalized treatment approaches and drug targets for AMD prevention and management.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $646.2k | 4/2/26 |