This federal Project Grant award of $256,296 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) aims to develop and validate a new optical coherence tomography angiography (OCTA) technology that can expand the depth range for imaging retinal microvasculature. The proposed work involves developing a high-speed adaptive ranging OCTA system leveraging integrated photonic components to improve the visualization of the peripheral retinal microvasculature, which is...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $215,454 to Duke University to develop a robotic optical coherence tomography (OCT) system capable of automatically measuring outer retinal layer thicknesses. The two-year project, starting September 1, 2024, aims to leverage the micrometer-scale control of the OCT sample beam position to acquire retinal volumes that fully visualize the Henle's fiber layer and outer nuclear...
This $433,841 federal Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports the development of computational methods and deep learning models to analyze imaging data and identify biomarkers for age-related macular degeneration (AMD). The goal is to improve understanding of AMD disease progression and response to treatment. Specifically, the project will develop deep neural network models to analyze optical coherence tomography,...
The National Eye Institute (NEI) awarded a $193,168 Project Grant (CFDA 93.867 - Vision Research) to Duke University to develop a novel, auto-aligning hand-held optical coherence tomography (OCT) and OCT angiography (OCTA) probe for routine and high-quality retinal imaging in infants and children. The project aims to address the challenge of achieving consistent and repeatable OCT and OCTA data capture in uncooperative pediatric patients, which is critical for diagnosing and monitoring retinal...
The National Eye Institute (NEI) awarded a $253,500 Project Grant (CFDA 93.867 - Vision Research) to the Icahn School of Medicine at Mount Sinai to reconstruct a human blood-retina barrier and perfused vascular system to investigate the role of apolipoprotein E (APOE) variants in age-related macular degeneration (AMD). The project aims to leverage induced pluripotent stem cell technology to develop an in vitro human outer blood-retina barrier model that can spontaneously form sub-retinal...
The National Eye Institute (NEI) awarded a $241,068 Project Grant (CFDA 93.867 - Vision Research) to Oregon Health & Science University (OHSU) to develop a prototype instrument providing high-resolution, three-dimensional, panretinal imaging of the eye using innovative circular-ranging optical coherence tomography (OCT) technologies. The project aims to assess the feasibility of using this handheld OCT system to detect subclinical retinoblastoma tumors and quantify tumor volumes in sedated...
The National Eye Institute (NEI) awarded a $623,090 Project Grant (CFDA 93.867 - Vision Research) to Oregon Health & Science University (OHSU) to develop an advanced visible-light optical coherence tomography (VIS-OCT) system and analytical methods for evaluating the oxygen-induced retinopathy (OIR) animal model. The goal is to build a wide-field VIS-OCT device capable of quantifying retinal blood flow, oxygen saturation, and vascular changes associated with OIR, which models retinopathy...
This Project Grant award of $285,504 from the National Eye Institute (CFDA 93.867 Vision Research) will fund research to develop a novel combined optical coherence elastography (OCE) and Brillouin microscopy system. The objective is to quantitatively evaluate the depth-dependent biomechanical properties of the human lens in vivo, which is critical for understanding and treating presbyopia. The research will validate the system's performance in ex-vivo porcine lenses and then test it for...
The National Eye Institute (NEI) awarded Oregon Health & Science University a $247,800 Project Grant under the Vision Research federal grant program (CFDA 93.867) to develop novel tools for diagnosing and classifying uveitis, a common cause of blindness in the United States. The project aims to leverage artificial intelligence and ultrahigh-resolution optical coherence tomography (OCT) to characterize the distribution and type of inflammatory response within the eye. Specifically, the...
The National Eye Institute (NEI) awarded a $3,120,397 Project Grant (CFDA 93.867 - Vision Research) to The Medical University of South Carolina to assess the role of the complement pathway in age-related macular degeneration (AMD). The project aims to utilize a 3D tissue chip model of the retinal pigment epithelium (RPE) and choroid to characterize the effects of genetic risk factors and environmental stressors on complement activation and AMD progression. Sub-awards were made to The...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $673,747 to New York University School of Medicine to develop a visible-to-near-infrared spanning optical coherence tomography (OCT) system. The system will enable high-resolution, depth-resolved imaging of key biomarkers related to aging and early age-related macular degeneration (AMD), including macular pigments and retinal pigment epithelium melanosomes. The goal is to establish these novel biomarkers as early indicators of AMD risk, which could identify patients who may benefit from emerging dry AMD treatments before significant vision loss occurs. The project will span 5 years, from June 2025 through May 2030.