This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $240,713 to investigate the role of the nuclear-encoded humanin isoform MTRNR2L1 in the pathogenesis of age-related macular degeneration (AMD), a leading cause of blindness. The research aims to elucidate whether MTRNR2L1 is a protein-coding gene or long non-coding RNA, and to examine its function in regulating mitochondrial activity and cell survival in retinal pigment epithelial cells under stress...
This Project Grant award from the National Eye Institute (NEI) of the National Institutes of Health (CFDA 93.867 - Vision Research) provides $658,889 to the University of Rochester to investigate the role of the pro-inflammatory enzyme PLA2G2A/sPLA2-IIA in age-related macular degeneration (AMD). The research aims to utilize human donor eyes, patient-derived induced pluripotent stem cells, and transgenic mouse models to critically evaluate the mutation-independent pathogenic role of PLA2G2A in...
This Project Grant award of $620,149 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports a multi-center research program to develop advanced genome editing technologies for modifying critical genetic risk factors associated with age-related macular degeneration (AMD). The research team, led by the University of Iowa, will conduct base editing and prime editing of AMD risk loci in human cells, including induced pluripotent stem...
This Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $253,500.00 to the Icahn School of Medicine at Mount Sinai to reconstruct a human blood-retina barrier and perfused vascular system. The goal is to investigate the role of apolipoprotein E (APOE) variants in age-related macular degeneration (AMD), a leading cause of vision loss. The research aims to optimize an in vitro outer blood-retina barrier model, generate isogenic models with different APOE...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), provides $547,898 to generate comprehensive datasets on mitochondrial DNA variation, DNA methylation, and chromatin accessibility changes in the retinal pigment epithelium and choroid tissues of human donor eyes across the spectrum of age-related macular degeneration (AMD). The goal is to elucidate the interplay between the nuclear and mitochondrial genomes that...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides USD 521,572.00 to East Tennessee State University to investigate the role of histone expression in retinal pigment epithelium (RPE) aging and its relationship to age-related macular degeneration (AMD). The research aims to define signatures of histone expression in the aging RPE and determine the cellular effects of histone depletion on RPE homeostasis and AMD progression....
This federal Project Grant award under the National Institutes of Health National Eye Institute's Vision Research program (CFDA 93.867) provides $513,371.00 to The Ohio State University to investigate the mechanisms by which oxidative stress triggers cellular signaling pathways that contribute to age-related macular degeneration (AMD) and other debilitating ocular diseases. The 5-year project aims to elucidate how oxidative stress causes the release of self-DNA into the cytosol, activating the...
This Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) for $3,120,397 will support the development and characterization of a 3D tissue chip model of the retinal pigment epithelium (RPE)-choroid complex to study the role of genetic risk factors and environmental stressors in the early pathogenesis of age-related macular degeneration (AMD). The research team, led by investigators at the Medical University of South Carolina, will utilize induced pluripotent stem...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) will provide $1,173,062 to The University of Iowa to investigate the role of extracellular matrix stiffness and genetic risk factors in age-related macular degeneration (AMD)-associated epithelial-to-mesenchymal transition. The research aims to determine how changes in matrix biomechanics impact the fate of retinal pigmented epithelial and choroidal endothelial cells using in vitro and ex vivo models of...
This Project Grant award, funded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867), supports a research project focused on understanding genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The total award amount is $385,000.00 over a 4-year period from August 1, 2025 to July 31, 2029. The project, led by researchers at Wayne State University, aims to compare the transcriptional, cellular, and functional...