Project Grant R01EY037230
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded a three-year Project Grant totaling $2,674,763 to Centre Hospitalier De L'Université De Montréal (CHUM) beginning September 30, 2025, with completion targeted for September 29, 2028. This award funds research investigating interpericyte tunneling nanotubes (IPTNTs) as therapeutic targets for glaucoma treatment and vision restoration. The research will generate empirical findings...
- Federal Grant Award Summary Award Details: The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded a Project Grant of $802,355 to President and Fellows of Harvard College (operating as Harvard Medical School) beginning May 1, 2026 and extending through February 28, 2030. The research is being conducted at the institution's Boston, Massachusetts facilities. Research Products and Deliverables: This award funds fundamental neuroscience research investigating how...
- Federal Project Grant Award Summary The National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) awarded $902,000 to the University of California, San Francisco for a two-year project (September 1, 2025 – August 31, 2027) to conduct multimodal characterization of a novel inherited mouse model of glaucoma. The primary deliverables include comprehensive phenotypic characterization of GLIS1 knockout mice across two genetic backgrounds, evaluating structural and functional...
- Federal Grant Award Summary Albert Einstein College of Medicine received a $414,711 Project Grant from the National Eye Institute (NEI) Vision Research program (CFDA 93.867), awarded June 1, 2025, with completion targeted for May 31, 2029. The award supports the development and utilization of a microphysiological system to elucidate mechanisms underlying early optic disc and stalk development, retinal ganglion cell (RGC) differentiation, axon growth, and pathfinding in human development and...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded a $764,881 Project Grant to the University of Colorado-Denver on September 15, 2025, to investigate the role of advanced glycation end products (AGEs) in primary open angle glaucoma (POAG). Primary open angle glaucoma is the most common form of glaucoma, accounting for approximately 80% of all glaucoma cases globally and affecting 80 million people, with 11 million...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded $427,625 under the Vision Research program (CFDA 93.867) to The Washington University for a two-year project (April 1, 2026 – March 31, 2028) to develop novel statistical methodologies for detecting and characterizing visual field progression in primary open-angle glaucoma (POAG). The primary deliverables include: (1) a change-point statistical model integrating longitudinal mean deviation measures to identify early disease...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $173,016 to the Whitehead Institute for Biomedical Research under the Vision Research program (CFDA 93.867) for a project grant effective August 1, 2025, through July 31, 2027. This award supports systematic identification and mechanistic characterization of novel oxidative protective genes to prevent retinal pigment epithelium (RPE) degeneration in age-related macular degeneration (AMD). The research involves...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $255,722 under the Vision Research program (CFDA 93.867) to the University of California, Berkeley, effective September 15, 2025, through August 31, 2027. This Project Grant supports fundamental research investigating the role and regulation of optic nerve microglia in glaucomatous neuropathy. The research deliverables include scientific findings on how lipoxin B4 (LXB4), an endogenous lipoxin produced by retinal...
- Federal Grant Award Summary Baylor College of Medicine received a $1,093,095 Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research program) effective July 1, 2025 through March 31, 2030, to investigate the role of vascular ligands and neurovascular dysfunction in glaucoma pathogenesis and to identify therapeutic targets for neuroprotection. The research leverages an innovative ligandomics technology platform to globally map cell-binding ligands with binding...
- Federal Grant Award Summary Emory University received a $617,201 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) effective July 1, 2025, through March 31, 2030. The award supports research to understand axonal injury mechanisms in glaucomatous optic neuropathy by leveraging innovative tools from engineering, artificial intelligence (AI), and advanced imaging techniques, specifically optical coherence tomography (OCT). The research aims to...
The National Eye Institute (NEI) awarded The Schepens Eye Research Institute, Inc. a Project Grant of $545,948 under the Vision Research program (CFDA 93.867) to advance understanding of glaucoma pathophysiology. The award, effective April 1, 2026 through March 31, 2030, supports research investigating the role of reactive astrocytes in glaucoma progression and retinal ganglion cell (RGC) survival. The research aims to move beyond traditional neurocentric approaches to examine non-neuronal cellular responses in the optic nerve head, specifically how astrocyte metabolic dysfunction and altered support mechanisms contribute to glaucoma-related vision loss when standard intraocular pressure-lowering treatments prove ineffective. The project will deliver empirical research findings on astrocyte reactive responses to ocular hypertension, including characterization of metabolic pathway alterations, mitochondrial biogenesis, and the mechanisms by which astrocytes provide metabolic support to stressed neurons. Deliverables will include scientific data on whether astrocyte-to-neuron mitochondrial trafficking and metabolic substrate provision represent viable therapeutic targets for neuroprotection, potentially identifying novel treatment strategies beyond current intraocular pressure management. Research will be conducted at the Boston-based institute in collaboration with Harvard Medical School and Massachusetts Eye and Ear.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $545.9k | 4/2/26 |