Project Grant R01EY038520
- Federal Grant Award Summary Cleveland Clinic Lerner College of Medicine of Case Western Reserve University received a $574,158 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) effective September 1, 2025, through April 30, 2030. The research project investigates the role of melanopsin in photoreceptor outer segment renewal, a fundamental homeostatic mechanism essential for maintaining lifelong photoreceptor health and vision. The research will...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
- Federal Grant Award Summary Baylor College of Medicine received a $646,167 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective April 1, 2026 through March 31, 2031. The award funds investigations into the cellular and molecular mechanisms underlying Age-Related Macular Degeneration (AMD), the leading cause of vision loss in elderly populations. The research applies high-throughput functional genomics approaches to identify causal...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded New York University School of Medicine a $673,747 Vision Research project grant (CFDA 93.867) commencing June 1, 2025, and concluding May 31, 2030, to develop advanced optical imaging technology for early detection of age-related macular degeneration (AMD). The research focuses on advancing visible-to-near-infrared spanning optical coherence tomography (OCT) to achieve half-micron axial resolution for retinal imaging,...
- Federal Project Grant Award Summary The National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) awarded $733,137 to the University of California, Los Angeles on September 15, 2025, to support research exploring how genetic variation influences disease progression and therapeutic response in age-related macular degeneration (AMD). The project, with completion targeted for March 31, 2030, will deliver scientific research products including refined classification of AMD...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $173,016 to the Whitehead Institute for Biomedical Research under the Vision Research program (CFDA 93.867) for a project grant effective August 1, 2025, through July 31, 2027. This award supports systematic identification and mechanistic characterization of novel oxidative protective genes to prevent retinal pigment epithelium (RPE) degeneration in age-related macular degeneration (AMD). The research involves...
- Federal Project Grant Award Summary Award Details: The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded a $504,304 Project Grant to Tufts University School of Medicine on April 15, 2026, with a project completion date of March 31, 2031. The award supports research investigating the mechanistic basis of the gut-retina axis and its relationship to age-related macular degeneration (AMD) prevention. Research Products and Services: The project will deliver...
- Federal Grant Award Summary The National Eye Institute (NEI), administering funds under the Vision Research program (CFDA 93.867), awarded the University of Maryland, Baltimore a $249,000 Project Grant effective September 30, 2025, with completion targeted for August 31, 2028. This research project will develop and validate novel fluorescence lifetime imaging technologies to assess the retinal pigment epithelium (RPE) cell mosaic in the living human eye by characterizing intracellular pigment...
- Federal Grant Award Summary The University of Rochester received a $658,889 Project Grant from the National Eye Institute (NEI) Vision Research program (CFDA 93.867) effective July 1, 2025, through April 30, 2029. This award supports research investigating the role of phospholipase A2 group IIA (PLA2G2A/SPLA2-IIA) in age-related macular degeneration (AMD), a leading cause of adult blindness. The research will employ a multi-faceted approach utilizing human donor eyes, patient-derived induced...
- Summary of Federal Project Grant Award The National Eye Institute (NEI) awarded a $422,125 Project Grant to the University of Miami's Office of Research Administration—School of Medicine on August 1, 2025, under the Vision Research program (CFDA 93.867) for a two-year project period concluding July 31, 2027. This award funds research investigating cholesterol homeostasis as a therapeutic target for demyelinating eye diseases, which are pathologies affecting the optic nerve that can cause...
The National Eye Institute (NEI) awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University a Project Grant totaling $615,928 (awarded April 15, 2026; completion March 31, 2030) under the Vision Research program (CFDA 93.867) to conduct mechanobiological research on Bruch's membrane during aging and its implications for age-related macular degeneration (AMD). The research will generate spatial and temporal matrisome maps—comprehensive protein composition analyses of the retinal pigment epithelium/Bruch's membrane/choriocapillaris complex—in both mouse and human eye tissue models to identify disease biomarkers and understand how changes in tissue stiffness contribute to AMD pathology. The primary research deliverables include characterization of extracellular matrix protein composition changes associated with aging, biomechanical stiffness mapping of Bruch's membrane across healthy and diseased states, and mechanistic insights into how alterations in tissue mechanics regulate retinal pigment epithelium barrier function and cellular metabolism. This fundamental research addresses a critical gap in understanding AMD etiology, as aging is a significant risk factor for this leading cause of blindness among elderly populations, and the complete matrisome of Bruch's membrane has not previously been described in the scientific literature.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $615.9k | 4/17/26 |