Project Grant R03DE036394
- The National Institute of Dental and Craniofacial Research awarded a cooperative agreement to The Regents of the University of California, San Francisco for $525,127 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds XERO STUDY, a Phase I clinical investigation of CVGN8, an injectable neuromimetic hydrogel therapeutic designed to restore salivary gland function in patients with radiation-induced xerostomia. CVGN8 encapsulates cevimeline,...
- The National Institute of Dental and Craniofacial Research awarded The Regents of the University of California, San Francisco $696,710 on August 10, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the role of the genome organizer protein SATB1 in salivary gland maturation and regeneration. The research addresses the absence of viable long-term treatments for salivary gland dysfunction resulting from disease or chronic injury, particularly xerostomia...
- The National Institute of Dental and Craniofacial Research awarded the University of Arizona $371,900 on August 3, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop innovative methods for evidence synthesis in oral health research. The project addresses barriers in current oral health evidence synthesis by developing oral-health-specific artificial intelligence tools, methodological resources, and analytical approaches. Aim 1 validates and adapts AI tools...
- The National Institute of Dental and Craniofacial Research, part of the National Institutes of Health under the Department of Health and Human Services, awarded The University of Chicago $328,000 on August 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop and validate a microsimulation model of oral health lifetime outcomes and resource use in older adults. The project, titled "Development and Validation of the U.S. Oral Health Microsimulation...
- The National Institute of Dental and Craniofacial Research awarded the University of Texas Health Science Center at Houston $1,187,388 on May 15, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop, validate, and clinically evaluate PREDICT, an artificial intelligence-driven clinical decision support system for periodontitis diagnosis and risk stratification. Periodontitis affects 42 percent of U.S. adults and carries estimated misclassification rates of 32...
- The National Institute of Dental and Craniofacial Research awarded the University of Rochester $642,037 on August 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop and validate SmartTeeth++, an AI-powered digital platform for remote detection and prediction of early-stage oral diseases including dental caries and gingivitis. The project integrates computer vision, machine learning, biomedical engineering, and clinical dentistry to deliver three core...
- The National Institute of Dental and Craniofacial Research awarded the University of Texas Health Science Center at Houston $721,776 on July 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to establish secure open access to the BIGMOUTH Dental Data Repository and develop an AI-powered research platform. The project, titled "OPENMOUTH: Leveraging AI to Enhance Fairness in Dental Clinical Research," will fully de-identify clinical data from the largest...
- The National Institute of Dental and Craniofacial Research awarded The Regents of the University of California, San Francisco $451,000 on August 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the mechanisms of intrafibrillar mineralization of collagen fibrils through the polymer-induced liquid precursor (PILP) pathway. The research examines how calcium and phosphate ions are captured and delivered to collagen mineralization sites, and explores the...
- The National Institute of Dental and Craniofacial Research awarded Icahn School of Medicine at Mount Sinai $150,590 on December 1, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research defining the role of tissue-resident macrophages (TRMs) during salivary gland morphogenesis. The research addresses salivary gland dysfunction caused by conditions such as Sjögren's syndrome and head and neck cancer irradiation, which lead to hyposalivation and...
- The National Institute of Dental and Craniofacial Research awarded $1.368593 million to The Regents of the University of California, San Francisco on July 15, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate aberrant mechano-oxygen coupling as a driver of zinc-enriched ectopic mineralization in osteoarthritis. The research integrates complementary expertise across three principal investigators. Longitudinal studies in rats with overloaded...
The National Institute of Dental and Craniofacial Research awarded The Regents of the University of California, San Francisco $328,000 on August 28, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop and validate an electronic health record–based phenotype of xerostomia and build a preliminary AI-driven risk prediction model for oral health complications. The project develops natural language processing methods to extract xerostomia cases and social risk factors from unstructured clinical notes in UCSF's de-identified clinical data warehouse. Current diagnostic approaches rely on structured data such as ICD codes, which have poor sensitivity for xerostomia; the research addresses a critical gap in identifying patients at highest risk for severe oral health complications. The project analyzes real-world clinical data to characterize comorbidities, social risk factors, and predict oral health outcomes using both structured and unstructured EHR data. Performance occurs at UCSF in San Francisco, California, over a two-year period from August 28, 2026, through August 27, 2028. This is a Project Grant (R03), a category supporting preliminary research and development.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $328.0k | 8/28/26 |