Cooperative Agreement UG3DE036295
- The National Institute of Dental and Craniofacial Research awarded The Regents of the University of California, San Francisco $696,710 on August 10, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the role of the genome organizer protein SATB1 in salivary gland maturation and regeneration. The research addresses the absence of viable long-term treatments for salivary gland dysfunction resulting from disease or chronic injury, particularly xerostomia...
- The National Institute of Dental and Craniofacial Research awarded The Regents of the University of California, San Francisco $328,000 on August 28, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop and validate an electronic health record–based phenotype of xerostomia and build a preliminary AI-driven risk prediction model for oral health complications. The project develops natural language processing methods to extract xerostomia cases and social risk...
- The National Institute of Dental and Craniofacial Research awarded Icahn School of Medicine at Mount Sinai $150,590 on December 1, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research defining the role of tissue-resident macrophages (TRMs) during salivary gland morphogenesis. The research addresses salivary gland dysfunction caused by conditions such as Sjögren's syndrome and head and neck cancer irradiation, which lead to hyposalivation and...
- The National Institute of Dental and Craniofacial Research awarded The Regents of the University of California, San Francisco $451,000 on August 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the mechanisms of intrafibrillar mineralization of collagen fibrils through the polymer-induced liquid precursor (PILP) pathway. The research examines how calcium and phosphate ions are captured and delivered to collagen mineralization sites, and explores the...
- The National Institute of Dental and Craniofacial Research awarded the University of Missouri System $304,650 on July 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to engineer cell sheets that restore salivary gland function in irradiated mice. The research addresses permanent salivary gland damage caused by radiation therapy for head and neck cancer, for which current treatments—saliva substitutes and secretory agonists—remain largely ineffective. The project...
- The National Institute of Dental and Craniofacial Research awarded $1.368593 million to The Regents of the University of California, San Francisco on July 15, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate aberrant mechano-oxygen coupling as a driver of zinc-enriched ectopic mineralization in osteoarthritis. The research integrates complementary expertise across three principal investigators. Longitudinal studies in rats with overloaded...
- The National Institute of Dental and Craniofacial Research awarded Northern California Institute For Research And Education, Inc. $499,022 on August 15, 2026, to conduct research elucidating the role of GS-GPCR signaling at the bone-vascular interface under the Oral Diseases and Disorders Research program (CFDA 93.121). The project investigates molecular mechanisms by which GS-GPCR signaling in endothelial and perivascular cells contributes to osteogenesis and fibrosis, using fibrous dysplasia...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded The Washington University $427,625 on February 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds research to develop and evaluate radiation-guided theranostic agents for detecting and monitoring response to oral cancer treatment. The research leverages radiation-inducible antigens, specifically...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $451,000 Project Grant to The Regents of the University of California, San Francisco on August 8, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121). This award supports the development and comprehensive characterization of metastatic MYB-NFIB fusion adenoid cystic carcinoma (ACC) cell line models through August 7, 2027. The research addresses a critical clinical need, as ACC is a rare but...
- The National Institute of Dental and Craniofacial Research awarded Virginia Commonwealth University $181,736 on December 1, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct research on therapy-induced senescence as a therapeutic target in head and neck squamous cell carcinoma. The research investigates the cGAS-STING pathway as a mechanism regulating therapy-induced senescence—a dormant yet metabolically active cellular state that may contribute to tumor cell...
The National Institute of Dental and Craniofacial Research awarded a cooperative agreement to The Regents of the University of California, San Francisco for $525,127 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds XERO STUDY, a Phase I clinical investigation of CVGN8, an injectable neuromimetic hydrogel therapeutic designed to restore salivary gland function in patients with radiation-induced xerostomia. CVGN8 encapsulates cevimeline, an FDA-approved muscarinic agonist, within an oxidized alginate excipient and operates through sustained cholinergic signaling to reactivate resident salivary stem cells. The research addresses a significant unmet clinical need, as current standard-of-care therapies for radiation-induced xerostomia—a common sequela of head and neck cancer treatment—provide only palliative relief and do not restore gland function. Work is performed at UCSF in San Francisco, California, with a period of performance from September 1, 2026, through August 31, 2027. The cooperative agreement mechanism reflects NIDCR's support for basic, translational, and clinical research in dental, oral, and craniofacial health and disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $525.1k | 8/11/26 |