Project Grant R21DE035693
- Federal Project Grant Award Summary The University of California, San Francisco received a $902,000 Project Grant awarded on June 1, 2025, by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The research project, titled "Unraveling the Regulation of Transcription and Activity of Calcium Transporter SLC24A4 in Enamel Formation," will be conducted through May 31, 2027, in San Francisco, California....
- The National Institute of Dental and Craniofacial Research awarded Northern California Institute For Research And Education, Inc. $499,022 on August 15, 2026, to conduct research elucidating the role of GS-GPCR signaling at the bone-vascular interface under the Oral Diseases and Disorders Research program (CFDA 93.121). The project investigates molecular mechanisms by which GS-GPCR signaling in endothelial and perivascular cells contributes to osteogenesis and fibrosis, using fibrous dysplasia...
- The National Institute of Dental and Craniofacial Research awarded $593,876 to the Regents of the University of Michigan on August 7, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the molecular mechanisms regulating peritubular dentin mineralization and develop bioengineered strategies for targeted dentin reconstruction. The research uses six mouse models with varied amounts of dentin sialoprotein (DSP), dentin phosphoprotein (DPP), and chondroitin...
- The National Institute of Dental and Craniofacial Research awarded $1.368593 million to The Regents of the University of California, San Francisco on July 15, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate aberrant mechano-oxygen coupling as a driver of zinc-enriched ectopic mineralization in osteoarthritis. The research integrates complementary expertise across three principal investigators. Longitudinal studies in rats with overloaded...
- The National Institute of Dental and Craniofacial Research awarded The Regents of the University of California, San Francisco $693,185 on June 15, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate mechanistic insights into amelogenin alternative splicing and its regulatory roles in amelogenesis imperfecta. The research examines how the amelogenin gene undergoes alternative splicing to produce distinct protein versions and regulatory molecules, with...
- The National Institute of Dental and Craniofacial Research awarded The Regents of the University of California, San Francisco $696,710 on August 10, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the role of the genome organizer protein SATB1 in salivary gland maturation and regeneration. The research addresses the absence of viable long-term treatments for salivary gland dysfunction resulting from disease or chronic injury, particularly xerostomia...
- The National Institute of Dental and Craniofacial Research, within the Department of Health and Human Services National Institutes of Health, awarded the University of Illinois $320,660 on July 9, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop anionic nanohybrid aggregate formulations for early childhood caries prevention. The project addresses early childhood caries affecting approximately 25 percent of American preschool children, particularly those of...
- The National Institute of Dental and Craniofacial Research awarded the University of Maryland, Baltimore $311,000 on June 15, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate citrate regulation mechanisms in tooth enamel development. The research examines how solute carrier family 13 member 5 (SLC13A5) and progressive ankylosis protein (ANK) regulate amelogenesis through citrate signaling pathways. The study employs histological analysis, microCT imaging,...
- The National Institute of Dental and Craniofacial Research awarded Northwestern University $633,074 under the Oral Diseases and Disorders Research program (CFDA 93.121) on July 1, 2026, to conduct multiscale modeling of enamel dissolution in caries formation. The research addresses how compositional gradients and residual stresses in tooth enamel crystallites influence the dissolution process during caries lesion formation. The project examines the core-shell structure of enamel crystallites,...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded Michigan State University $298,613 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate cellulose nanocrystals as a strategy for reducing moisture sensitivity in dental adhesives. The research will determine how cellulose nanocrystals distribute within self-etch adhesive formulations and whether...
The National Institute of Dental and Craniofacial Research awarded The Regents of the University of California, San Francisco $451,000 on August 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the mechanisms of intrafibrillar mineralization of collagen fibrils through the polymer-induced liquid precursor (PILP) pathway. The research examines how calcium and phosphate ions are captured and delivered to collagen mineralization sites, and explores the inhibitory mechanisms—such as acidic and anionic protein domains—that regulate mineral formation in biological tissues. The work translates recent in vitro findings into a potential clinical methodology for remineralizing dentinal and osseous tissues. Performance occurs in San Francisco, California, with a period of performance through August 5, 2028. This is a Project Grant (R21 mechanism), assistance type Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $451.0k | 8/7/26 |