Project Grant R56DE036307
- Federal Project Grant Award Summary The University of California, San Francisco received a $902,000 Project Grant awarded on June 1, 2025, by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The research project, titled "Unraveling the Regulation of Transcription and Activity of Calcium Transporter SLC24A4 in Enamel Formation," will be conducted through May 31, 2027, in San Francisco, California....
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of California, San Francisco a $693,185 Project Grant on June 15, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct mechanistic research into amelogenin alternative splicing and its regulatory roles in enamel development. This five-year research initiative, with a completion date of March 31, 2031, focuses on understanding how mutations...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research awarded University of California Irvine a $1.215 million Project Grant effective August 22, 2025, through May 31, 2030, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds tissue-immunoengineering research to develop improved temporomandibular joint (TMJ) neodisc implants for treating TMJ disc perforations, a condition affecting millions of Americans. The research will...
- Federal Grant Award Summary Massachusetts General Hospital's Research Management Division received a $408,951 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded February 15, 2026, with completion targeted for February 14, 2028. The grant supports development and validation of photochemical tissue passivation (PTP), an innovative therapeutic approach utilizing photocrosslinking...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research awarded the University of Delaware a Project Grant of $368,438 on September 4, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate cellular heterogeneity and niche regulation in temporomandibular joint (TMJ) development and disease. The research project, scheduled for completion on May 31, 2030, aims to advance understanding of TMJ osteoarthritis—a...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded Columbia University's Health Sciences Division a $655,455 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) effective September 11, 2025, with completion targeted for September 10, 2027. This R01 renewal award supports fundamental and translational research to identify temporomandibular joint (TMJ) cartilage progenitor cells and characterize their...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Forsyth Institute a $706,281 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) on May 5, 2026, with completion scheduled for April 30, 2031. This research grant funds a five-year investigation into microRNA-mediated mechanisms in temporomandibular joint (TMJ) health and disease, with specific focus on how microRNAs regulate fibrocartilage stem/progenitor...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Children's Hospital of Philadelphia Research Institute a $507,006 Project Grant on August 1, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the role of hyaluronan in YAP (Yes-associated protein) signaling on temporomandibular joint (TMJ) health and pathology. The research will be conducted over a two-year period through July 31, 2027, and focuses...
- FEDERAL GRANT AWARD SUMMARY Periomics Care LLC received a $297,711 Project Grant awarded August 6, 2025, by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The Phase I study focuses on developing and testing zinc tetraammine difluoride (ZAF), a novel formulation designed to create zinc oxide and zinc hydroxyl fluoride nanocrystals for dental caries arrest and remineralization. This research aims to provide a...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded University of California, Los Angeles $180,943.00 under the Oral Diseases and Disorders Research program (CFDA 93.121) on June 13, 2025, for research addressing therapeutic targeting of apical periodontal T-cells in chronic oral inflammation. The research initiative, which extends through May 31, 2030, investigates the pathogenic mechanisms underlying apical periodontitis—a chronic...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded $1.37M to The Regents of the University of California, San Francisco under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the mechanisms of zinc-enriched ectopic mineralization in osteoarthritis. The two-year project, effective July 15, 2026, through July 14, 2028, will deliver research findings and analytical data examining how aberrant mechanical loading and oxygen availability trigger pathological mineralization at the cartilage-bone interface. The collaborative research team will conduct longitudinal animal studies using overloaded temporomandibular joint models to correlate force-induced angiogenesis with biomineralization, perform multimodal microspectroscopy analysis of zinc species distribution, and develop bioengineered organoid and microfluidic systems to elucidate the crosstalk between chondrocytes, osteoblasts, and vascular endothelial cells under mechanical stress and varying oxygen conditions. The research deliverables will include bioanalytical assays quantifying zinc levels, activity profiles, proteome data, and ligand identification in temporomandibular joint tissues. Through complementary expertise in longitudinal in vivo studies, multicellular organoid development, and bioanalytical assessment, the project will advance mechanistic understanding of force- and oxygen-dependent mineralization pathways implicated in osteoarthritis progression, with potential implications for understanding similar pathological mineralization processes affecting other load-bearing joints.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.4m | 7/8/26 |