This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research program (CFDA 93.121), provides $628,965.00 to the Icahn School of Medicine at Mount Sinai over a 5-year period from May 1, 2025 to April 30, 2030. The funding supports research to elucidate how immune cells, specifically tissue-resident macrophages, regulate the coordinated processes of salivary gland development and differentiation. The...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $714,711 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Icahn School of Medicine at Mount Sinai. The 5-year grant, which commenced on July 1, 2025, aims to investigate mechanisms that can specifically protect or regenerate salivary glands without benefiting cancer growth following radiation therapy. The research team developed a scalable gene targeting system to screen over...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $115,992 to The Research Foundation For The State University Of New York (RF SUNY) to develop human induced pluripotent stem cell (iPSC)-derived salivary gland organoids (SGOs) with secretory function and well-defined architecture. The project aims to utilize engineered viscoelastic hydrogels to optimize the...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $248,750.00 to the ADA Forsyth Institute, Inc. (The Forsyth Institute) to investigate the role of cellular senescence in salivary gland dysfunction associated with Sjögren's syndrome. The research aims to determine the impact of cellular senescence on Sjögren's syndrome-related xerostomia (dry mouth) and...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is providing $409,960.00 to Texas A&M University System Health Science Center to develop a human salivary gland-on-a-chip model. The goal is to create a platform that can faithfully replicate normal salivary gland function as well as model the effects of radiation-induced damage, in order to improve drug development efforts...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $644,970 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of Arizona. The grant will fund research over a 5-year period from July 1, 2025 to June 30, 2030 to investigate the role of immune-epithelial interactions in restoring salivary gland function after radiation therapy for head and neck cancer. The research aims to develop a kinetic model of the metabolic phenotype...
This federal Project Grant award of $339,000 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The funding supports research by New York University School of Medicine to investigate the role of autocrine cholinergic signaling in maintaining memory T cell responses in oral squamous cell carcinoma. The research project will be conducted from August 1, 2024 to July 31, 2026. As a leading...
The federal Project Grant award R00DE032363, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program, will fund research to explore the role of tuft cells in salivary gland immunity. The $608,632.33 award, spanning from Sep 1, 2024 to Mar 31, 2028, will support the following key objectives: (1) investigating tuft cell distribution and function in salivary gland epithelium, (2) determining tuft cell...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $491,193 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of California, San Diego (UCSD) for the project "Engineering Mucin Analogues to Benefit the Mouth Environment." The project aims to create advanced mucin substitutes that closely emulate the physiological functions of natural salivary mucins, in order to develop enhanced artificial saliva...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $231,492 to develop an in vitro salivary gland Sjogren's syndrome (SS) tissue chip (SSTC) platform. The goal is to use this SSTC platform to investigate the effects of endocrine-disrupting chemicals on the growth and function of salivary gland tissue mimetics. The project will also perform RNA sequencing studies...