Project Grant R01EY037540
- The National Eye Institute awarded The University of Chicago $582,115 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the role of lens connexins, cellular stress, and ionic imbalance in cataract formation. The research will define pathogenic mechanisms linking disruption of lens ionic homeostasis and formation of calcium-containing deposits to cataract development. The project utilizes human lens material, mutant mouse models, and in vitro systems to...
- The National Eye Institute awarded the University of North Texas Research and Innovation Division $564,489 on September 1, 2026, under the Vision Research program (CFDA 93.867) to conduct a large-scale epidemiological study examining occupational chemical and non-chemical exposures in relation to cataract risk. The project, titled "Cataract Risk and Occupational Exposures in Denmark," will extract data from established Danish health registers and apply validated job exposure matrices...
- The National Center for Advancing Translational Sciences at the National Institutes of Health awarded the University of Delaware $158,430 on June 1, 2026, under CFDA 93.350 (National Center for Advancing Translational Sciences) to characterize eye pathology associated with the protein TDRD7 and identify potential druggable pathways linked to the protein's function in the lens. The award supports research into TDRD7 mutations that cause congenital cataracts and azoospermia in humans. The research...
- The National Eye Institute awarded Miami University $467,969 on April 15, 2026, under the Vision Research program (CFDA 93.867) to investigate FOXE3's role in lens chromatin architecture and transcriptional identity. The research employs state-of-the-art chromatin and transcriptomic technologies, including single-nucleus multiomics (ATAC-seq and RNA-seq), CUT & RUN, and functional assays in chick embryos, to dissect FOXE3's molecular mechanisms in lens development. Aim 1 will identify...
- The National Institutes of Health National Eye Institute awarded New York University School of Medicine $428,247 on September 30, 2025, under the Vision Research program (CFDA 93.867) to investigate the mechanism of corneal lens development using Drosophila as a model organism. The research uses fly genetics, super-resolution microscopy, and electron microscopy to study how the polysaccharide chitin influences corneal lens morphogenesis and shape. The investigator will analyze the role of...
- The National Eye Institute, part of the Department of Health and Human Services, awarded Vanderbilt University $435,875 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the mechanism of formation and cataractogenic properties of gamma-S-crystallin cleavage products. The research addresses cataract formation at the molecular level by elucidating how S-crystallin cleavage occurs in aging lenses and the functional consequences of such modification. The work...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded $628,100 to the University of Miami on May 1, 2026, under the Vision Research program (CFDA 93.867) to advance understanding of lens remodeling in childhood myopia development and progression. The project will develop new technologies to measure three-dimensional lens shape, ocular biometry, central and peripheral refraction, and accommodation-related changes in children. The...
- The National Eye Institute awarded the University of Cincinnati Sponsored Research Services $445,500 on June 1, 2026, under the Vision Research program (CFDA 93.867) to conduct fate mapping and functional analysis of COL8A2-positive cells in corneal endothelial development and disease. The recipient will generate a tamoxifen-inducible COL8A2P2A-CREERT2 mouse line to enable temporal and tissue-specific labeling and manipulation of COL8A2-positive cells. In Aim 1, the team will use lineage tracing...
- The National Eye Institute awarded Duke University $629,520 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the structural and functional roles of the cyclic nucleotide-gated (CNG) channel and sodium/potassium/calcium exchanger (NCKX) complex in maintaining photoreceptor outer segment integrity. The research addresses how photoreceptor cells construct and sustain their light-sensitive outer segment organelles—modified cilia containing stacked disc membranes...
- The National Eye Institute, an office of the National Institutes of Health within the Department of Health and Human Services, awarded The University of Iowa $427,625 on September 1, 2026, under the Vision Research program (CFDA 93.867) to develop mutation-independent gene therapy vectors for CEP290-associated Leber congenital amaurosis, a hereditary retinal dystrophy causing severe vision loss in infants and early childhood. The recipient will engineer and evaluate adeno-associated virus...
The National Eye Institute awarded the University of Delaware $390,764 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate regulatory networks controlling lens development and homeostasis as a means of understanding cataract pathology and prevention. The award funds research on transcriptional and post-transcriptional gene expression control mechanisms in lens development. The recipient will test a hypothesis that ELL2 (elongation factor for RNA polymerase II 2), a regulator previously believed to have only general roles in gene expression, selectively controls the massive transcriptional upregulation of key lens messenger RNAs whose mutations or deficiency cause human cataract. The work uses an ELL2-targeted lens conditional knockout mouse model to examine how ELL2 is regulated by cataract-linked RNA-binding proteins and coordinates with other lens regulatory networks. The research applies ISYTE (Integrated Systems Tool for Eye Gene Discovery), a web-based resource the recipient developed to predict pathways linked to eye and lens defects. Performance occurs in Newark, Delaware, with a period of performance from September 1, 2026, through August 31, 2030. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $390.8k | 9/2/26 |