Project Grant R01EY038335
- The National Eye Institute awarded Duke University $405,373 on June 1, 2026, under the Vision Research program (CFDA 93.867) to characterize bicornuate cones, a novel type of cone photoreceptor cell discovered in the human retina that contains two fully developed outer segments emanating from a single inner segment. The project will conduct two specific aims. Aim 1 employs high-resolution ultrastructural analysis using three-dimensional electron tomography to determine the number of centrioles...
- The National Eye Institute awarded Duke University $485,871 for research on synaptic mechanisms of history-dependent visual processing under the Vision Research program (CFDA 93.867) beginning September 1, 2026. The award funds investigation of how adaptation dynamically regulates sensory systems in response to recent visual experience. The research examines cell-intrinsic, synaptic, and circuit mechanisms of adaptation in primary visual cortex across multiple timescales, testing the...
- The National Eye Institute awarded The Research Foundation For The State University of New York $456,915 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate molecular mechanisms of photoreceptor outer segment renewal, with performance at Syracuse, New York, through May 31, 2031. The project uncovers fundamental molecular mechanisms underpinning the constant renewal of photoreceptor outer segments, a process critical for vision. Defects in outer segment renewal...
- The National Eye Institute awarded Duke University $127,718 on December 21, 2025, under the Vision Research program (CFDA 93.867) to support cellular-level dissection of the visuomotor circuit in larval zebrafish, focusing on neural mechanisms that transform continuous visual motion signals into discrete motor commands. The research investigates how specific motion-selective neurons in the pretectum drive activation of recurrent inhibitory circuits composed of midbrain spinal projection neurons,...
- The National Eye Institute awarded The University of Chicago $582,115 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the role of lens connexins, cellular stress, and ionic imbalance in cataract formation. The research will define pathogenic mechanisms linking disruption of lens ionic homeostasis and formation of calcium-containing deposits to cataract development. The project utilizes human lens material, mutant mouse models, and in vitro systems to...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded $624,743 to the Regents of the University of California, doing business as University of California, Berkeley, on May 1, 2026, under the Vision Research program (CFDA 93.867). The award funds research into the function and regulation of constitutive prostaglandin D2 and DP receptor signaling in retinal health and neurodegeneration. The research investigates the physiological and...
- The National Eye Institute awarded Duke University $163,160 on February 8, 2027, under the Vision Research program (CFDA 93.867) to support research on the diversification of closely related bipolar cell types in retinal development. The funded research uses bipolar cells of the mouse retina as a model system to determine the developmental timing when bipolar cell types first become molecularly distinct and how these distinctions confer unique functional properties in mature types. The work...
- The National Eye Institute awarded Duke University $534,783 on July 1, 2026, through the Vision Research program (CFDA 93.867) to establish the Duke Ophthalmology Mentored Physician Scientist Program, a career development initiative for early-career ophthalmology physician scientists. The program will train two qualified physician scientist scholars per year through a five-year period of performance ending June 30, 2031. Training emphasizes multidisciplinary research in clinical,...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded The University of Chicago $929,806 on September 30, 2025, under the Vision Research program (CFDA 93.867). The award funds research into synaptic development of the retinogeniculate pathway—the neural circuit connecting the eyes to the brain—with investigation focused on how neurons form correct connections during childhood development and how visual experience shapes that...
- The National Eye Institute awarded the University of California, Berkeley $153,560 on February 18, 2027, under the Vision Research program (CFDA 93.867) to investigate the ultrastructural development and regeneration of nodes of Ranvier in the mouse optic nerve. The project applies cryo-electron tomography (cryo-ET) with laser phase plate enhancement to visualize nodal protein complexes in situ and understand how ion channel scaffolding proteins establish and maintain rapid neural signaling. Aim...
The National Eye Institute awarded Duke University $629,520 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the structural and functional roles of the cyclic nucleotide-gated (CNG) channel and sodium/potassium/calcium exchanger (NCKX) complex in maintaining photoreceptor outer segment integrity. The research addresses how photoreceptor cells construct and sustain their light-sensitive outer segment organelles—modified cilia containing stacked disc membranes that capture light and house signaling proteins. The project tests the hypothesis that the CNG channel's β-subunit, rather than the previously assumed α-subunit, provides critical structural support linking disc rims to the outer segment plasma membrane, with implications for understanding photoreceptor function and vision diseases. The work will examine the roles of individual subunits within the CNG channel/NCKX exchanger complex and their interactions in supporting outer segment structural and functional integrity. Performance is at Duke University's Office of Research Administration in Durham, North Carolina, with a completion date of May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $629.5k | 8/21/26 |