Project Grant R01EY036378
- Summary of Federal Project Grant Award The National Eye Institute (NEI) awarded a $422,125 Project Grant to the University of Miami's Office of Research Administration—School of Medicine on August 1, 2025, under the Vision Research program (CFDA 93.867) for a two-year project period concluding July 31, 2027. This award funds research investigating cholesterol homeostasis as a therapeutic target for demyelinating eye diseases, which are pathologies affecting the optic nerve that can cause...
- Federal Grant Award Summary The University of Florida's Division of Sponsored Research received a $479,417 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) effective August 1, 2025, through July 31, 2030. This research initiative, titled "Visuocortical Foundations of Development," will deliver comprehensive scientific investigation into the developmental trajectory of infant visual system function and its predictive...
- Federal Grant Award Summary Emory University received a $391,250 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded July 1, 2025, with a completion date of June 30, 2030. The award supports basic science research investigating how visual input influences neuronal signaling pathways related to myopia (nearsightedness) development. The project will employ single-cell electrophysiological recordings to examine ON and OFF retinal pathway...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $435,052 Vision Research (CFDA 93.867) Project Grant to the University of Massachusetts Boston for the period July 1, 2025 through June 30, 2029. This research project will investigate the molecular and genetic mechanisms that control photoreceptor subtype specification for color vision in the fruit fly (Drosophila melanogaster) retina as a model system. The research will identify conserved transcription factors and...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
- Federal Grant Award Summary Rochester Institute of Technology received a $143,569 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) for the period July 1, 2025 through June 30, 2029. The award supports fundamental research to establish the multi-component phase diagram and statistical-thermodynamic molecular basis of concentrated, aqueous eye lens crystallin protein mixtures. This research directly addresses cataract disease, the leading cause of...
- Federal Grant Award Summary Award Details: The National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), awarded Michigan State University $869,589 for a three-year project period (May 1, 2025 – April 30, 2028) to develop and validate a new animal model for studying evaporative dry eye disease (EDED). Research Products and Services: This project will establish EDED pathogenesis research capabilities through characterization of AWAT2 knockout (KO) mice, which...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $173,016 to the Whitehead Institute for Biomedical Research under the Vision Research program (CFDA 93.867) for a project grant effective August 1, 2025, through July 31, 2027. This award supports systematic identification and mechanistic characterization of novel oxidative protective genes to prevent retinal pigment epithelium (RPE) degeneration in age-related macular degeneration (AMD). The research involves...
- Federal Grant Award Summary The National Eye Institute (NEI), administering funds under the Vision Research program (CFDA 93.867), awarded the University of Maryland, Baltimore a $249,000 Project Grant effective September 30, 2025, with completion targeted for August 31, 2028. This research project will develop and validate novel fluorescence lifetime imaging technologies to assess the retinal pigment epithelium (RPE) cell mosaic in the living human eye by characterizing intracellular pigment...
- Federal Grant Award Summary New York University School of Medicine received a $285,498 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) effective September 30, 2025, with an ultimate completion date of August 31, 2027. This research grant funds fundamental scientific investigation into corneal lens development mechanisms using Drosophila (fruit fly) as a model organism to better understand human corneal curvature disorders including...
Miami University received a $467,969 Project Grant from the National Eye Institute (CFDA 93.867, Vision Research program) awarded on April 15, 2026, with a completion date of March 31, 2031. The project, titled "FOXE3 in Creating Lens Chromatin Architecture and Transcriptional Identity," will deliver fundamental research findings on the molecular mechanisms by which the FOXE3 transcription factor regulates lens cell development and suppresses pro-neurogenic gene expression. Research products will include empirical data from single-nucleus multiomics analyses (Assay for Transposase-Accessible Chromatin sequencing combined with RNA-sequencing), Cleavage Under Targets and Release Using Nuclease (CUT & RUN) mapping of FOXE3-bound regulatory elements, characterization of FOXE3-dependent chromatin accessibility alterations in mutant lenses, and functional validation studies conducted in chick embryos. The award supports advanced molecular and genomic research aimed at understanding cell fate determination in ocular lens development, a process relevant to vision disease prevention and treatment. Through integration of state-of-the-art chromatin and transcriptomic technologies, the research will identify FOXE3 transcriptional targets and map FOXE3-dependent regulatory landscapes in lens tissue. These research outputs will contribute to the National Eye Institute's mission to drive innovative research for understanding the eye and visual system and preventing vision diseases.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $468.0k | 4/17/26 |