Project Grant R56EY037739
- The National Eye Institute awarded the University of North Texas Research and Innovation Division $564,489 on September 1, 2026, under the Vision Research program (CFDA 93.867) to conduct a large-scale epidemiological study examining occupational chemical and non-chemical exposures in relation to cataract risk. The project, titled "Cataract Risk and Occupational Exposures in Denmark," will extract data from established Danish health registers and apply validated job exposure matrices...
- The National Eye Institute, part of the Department of Health and Human Services, awarded Vanderbilt University $435,875 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the mechanism of formation and cataractogenic properties of gamma-S-crystallin cleavage products. The research addresses cataract formation at the molecular level by elucidating how S-crystallin cleavage occurs in aging lenses and the functional consequences of such modification. The work...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded The University of Chicago $929,806 on September 30, 2025, under the Vision Research program (CFDA 93.867). The award funds research into synaptic development of the retinogeniculate pathway—the neural circuit connecting the eyes to the brain—with investigation focused on how neurons form correct connections during childhood development and how visual experience shapes that...
- The National Eye Institute awarded the University of Delaware $390,764 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate regulatory networks controlling lens development and homeostasis as a means of understanding cataract pathology and prevention. The award funds research on transcriptional and post-transcriptional gene expression control mechanisms in lens development. The recipient will test a hypothesis that ELL2 (elongation factor for RNA polymerase II 2),...
- The National Eye Institute awarded Duke University $629,520 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the structural and functional roles of the cyclic nucleotide-gated (CNG) channel and sodium/potassium/calcium exchanger (NCKX) complex in maintaining photoreceptor outer segment integrity. The research addresses how photoreceptor cells construct and sustain their light-sensitive outer segment organelles—modified cilia containing stacked disc membranes...
- The National Eye Institute, a bureau of the Department of Health and Human Services National Institutes of Health, awarded $497,740 to the University of Illinois on April 1, 2026, under the Vision Research program (CFDA 93.867) to fund research into neuro-epithelial interactions in corneal disease and repair, with Principal Investigator Elmira Jalilian. The project investigates how corneal epithelial cells and trigeminal nerve fibers (the V1 ophthalmic branch) interact to maintain corneal...
- The National Eye Institute awarded The Schepens Eye Research Institute $858,394 on August 1, 2026, under the Vision Research program (CFDA 93.867) to develop multimodal foundation models for eye disease screening and prognosis. The research develops a vision-language foundation model trained on pairs of retinal images and clinical notes to enable downstream supervised models for detection and progression prediction of age-related macular degeneration, diabetic retinopathy, and glaucoma. The...
- The National Eye Institute awarded the University of Cincinnati Sponsored Research Services $445,500 on June 1, 2026, under the Vision Research program (CFDA 93.867) to conduct fate mapping and functional analysis of COL8A2-positive cells in corneal endothelial development and disease. The recipient will generate a tamoxifen-inducible COL8A2P2A-CREERT2 mouse line to enable temporal and tissue-specific labeling and manipulation of COL8A2-positive cells. In Aim 1, the team will use lineage tracing...
- The National Eye Institute awarded The Trustees of Columbia University in the City of New York $532,079 on September 1, 2026, under the Vision Research program (CFDA 93.867) to characterize the role of apelin signaling in Schlemm's canal development and its relationship to early-onset glaucoma. The research employs mouse models to express and trace the apelin receptor during Schlemm's canal development, uses conditional and inducible mouse models to study loss of apelin receptor function...
- The National Eye Institute awarded the University of California, Los Angeles $244,150 on April 15, 2026, under the Vision Research program (CFDA 93.867) to support a project grant investigating molecular gradients underlying wiring plasticity in the visual cortex. The research combines single-cell transcriptomics, epigenomics, connectomics, and computational analysis to link genes, cell types, regulatory networks, and circuit structure in layers 2 and 3 (L2/3) glutamatergic neurons in the...
The National Eye Institute awarded The University of Chicago $582,115 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the role of lens connexins, cellular stress, and ionic imbalance in cataract formation. The research will define pathogenic mechanisms linking disruption of lens ionic homeostasis and formation of calcium-containing deposits to cataract development. The project utilizes human lens material, mutant mouse models, and in vitro systems to examine how damage to lens proteins and cellular stress activation of proteolytic pathways relate to calcium deposition. The work focuses on connexin46 and connexin50 mutations and their effects on lens fiber cells. Findings may provide direction for preventative and therapeutic approaches to cataracts, the leading cause of blindness worldwide. Performance occurs in Chicago, Illinois, with a period of performance from September 1, 2026 through August 31, 2027. This Project Grant is a single-year award under NEI's peer-reviewed competitive research program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $582.1k | 9/2/26 |