Project Grant R03TR006304
- Federal Grant Award Summary The University of Delaware received a $155,559 Project Grant from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) awarded on June 17, 2025, with a completion date of May 31, 2026. The research project investigates the impact of the histone H3K9 methyltransferase SETDB1 on mitochondrial function and morphology. The study addresses a significant gap in understanding SETDB1's cytoplasmic roles, as altered activity of this protein has been...
- Federal Project Grant Award Summary The University of Delaware received a $1,355,976 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 1, 2026 through March 31, 2030. This award supports fundamental biomedical research investigating ADAM (disintegrin metalloproteinase) and ephrin protein interactions in cell signaling and adhesion. The research addresses a critical gap...
- Federal Project Grant Award Summary The University of Delaware received a $427,811 Project Grant from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) awarded on June 1, 2025, with a completion date of May 31, 2027. The grant funds development and validation of the "Total Inhalable Deposition in an Actuated Lung" (TIDAL) model, a multiscale preclinical tool designed to measure spatial aerosol deposition in human lungs under simulated breathing conditions....
- Federal Project Grant Award Summary The University of Delaware received a $460,953 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 1, 2026, through February 28, 2031. This award funds fundamental research investigating the subcellular transport, regulation, and function of ribonucleic acids (RNAs) during early embryonic development. The research focuses on understanding how...
- Federal Project Grant Award Summary The University of Delaware received a $350,000 Project Grant awarded on September 4, 2025, from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859). The award funds a research project titled "Cellular Heterogeneity and Niche Regulation in TMJ" extending through May 31, 2030. This project addresses temporomandibular joint osteoarthritis (TMJ-OA), a degenerative joint disease...
- Federal Project Grant Award Summary The University of Pennsylvania received a $1.2 million Project Grant from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) awarded July 1, 2025, through June 30, 2027, to advance clinical trial readiness for LCAT (lecithin-cholesterol acyltransferase) deficiency, an ultra-rare autosomal recessive genetic disorder. The project delivers three primary products: (1) identification of diagnostic and prognostic biomarkers to guide...
- Federal Grant Award Summary The University of Delaware received a $560,380 Project Grant from the National Institute on Aging (CFDA 93.866—Aging Research) awarded January 15, 2026, with completion targeted for December 31, 2028. The award funds the development and application of a novel force-sensing universal robotic testing system to conduct in situ biomechanical analysis of mouse knee joints in both healthy and osteoarthritis-affected states. The primary deliverable is a sophisticated...
- Federal Project Grant Award Summary The University of Delaware received a $430,063 Project Grant awarded on August 10, 2025, by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports the development of photoacoustic imaging technology to improve endometriosis diagnosis and treatment through August 31, 2027. The research will produce inflammation-targeted nanoparticles...
- Federal Grant Award Summary The Children's Hospital of Philadelphia Research Institute received a $489,500 Project Grant award from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) effective September 3, 2025, through September 2, 2027. This grant funds the development of patient-centric clinical outcome measures for Multiple Sulfatase Deficiency (MSD), an ultra-rare, fatal neurodegenerative disorder with emerging therapeutic options including AAV-based gene...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
The University of Delaware received a $158,430 Project Grant from the National Center for Advancing Translational Sciences (NCATS), CFDA 93.350, awarded on June 1, 2026, with a completion date of May 31, 2027. This grant supports research characterizing eye pathology associated with TDRD7 (Tudor family RNA-binding protein), an understudied protein linked to a rare human syndrome featuring congenital cataracts and azoospermia (defective sperm formation). The research addresses a critical knowledge gap by identifying potential druggable pathways associated with TDRD7 function in lens differentiation and development, with the goal of advancing new therapeutic interventions beyond current surgical-only treatment options. The funded research employs a dual mechanistic hypothesis positing that TDRD7 participates in both post-transcriptional control and chromatin control to regulate gene expression in the lens. The project utilizes TDRD7 knockout mouse models to examine how TDRD7 loss causes cellular morphology defects in mature lens fibers and reduced expression of genes linked to lens defects in humans and animals. Deliverables include experimental findings on TDRD7's protein-RNA complex participation in the fiber cytoplasm and its nuclear localization during mid-embryonic stages, providing foundational knowledge to support the development of targeted therapeutics for congenital cataracts and related vision disorders.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $158.4k | 5/8/26 |