Project Grant R21EY038860
- Federal Project Grant Award Summary The University of Iowa received a $641,479 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded May 1, 2026, with completion scheduled for February 28, 2031. This award funds research to identify molecular signals leading to the onset and progression of Fuchs Endothelial Corneal Dystrophy (FECD) phenotypes using a newly developed mouse model. FECD is a blinding disease affecting 4-7% of individuals over...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded The Ohio State University $433,125 on August 1, 2025, to investigate tissue factor (TF) as a potential biomarker and therapeutic target for corneal neovascularization (CNV). This two-year project, concluding July 31, 2027, addresses a significant unmet medical need, as CNV—the pathological growth of blood vessels in the cornea—is a common sequela of corneal diseases...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $527,987 Project Grant to the University of California, Los Angeles (UCLA) for the period May 1, 2026 through April 30, 2030 under the Vision Research program (CFDA 93.867). The award supports the development of an engineered, tunable biomimetic adhesive hydrogel platform designed to deliver mesenchymal stem cells (MSCs) to the cornea for regeneration and repair. The research addresses a critical bottleneck in corneal disease...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded The Schepens Eye Research Institute, Inc. a Project Grant totaling $540,213 under the Vision Research program (CFDA 93.867) to investigate the fibrosis-immunity interface in corneal transplantation. Beginning August 1, 2025, and extending through July 31, 2030, this research program will deliver scientific findings aimed at improving corneal transplant survival rates by elucidating the mechanisms by which myofibroblasts...
- Federal Grant Award Summary The University of North Texas Health Science Center at Fort Worth received a $249,000 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded April 15, 2026, with a completion date of March 31, 2029. This award supports research aimed at developing non-surgical treatments for keratoconus, a progressive corneal disorder affecting approximately 1 in 500 to 2,000 Americans. The research focuses on inhibiting...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $405,373 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded June 1, 2026, with a completion date of May 31, 2028. The grant funds fundamental research to characterize bicornuate cones, a novel type of photoreceptor cell recently identified in the human retina that contains two fully developed outer segments emanating from a single cell soma—a...
- Federal Grant Award Summary The University of Illinois received a $497,740 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective April 1, 2026 through March 31, 2031. Principal Investigator Elmira Jalilian will conduct research investigating neuro-epithelial interactions in corneal disease and repair, with performance occurring in Chicago, Illinois. The research addresses diabetic corneal neuropathy, which affects approximately 50% of...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded University of California, Irvine $179,964 under the Vision Research program (CFDA 93.867) on March 1, 2025, for a project grant extending through July 10, 2029. The project focuses on developing deep learning-based biomarkers for optic neuropathies using retinal Optical Coherence Tomography (OCT) imaging analysis. The research will employ advanced computational techniques, including deep generative models, neural field image...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $900,600 Project Grant to The Regents of the University of California, San Francisco, effective September 1, 2025, through August 31, 2027, to support research aimed at understanding corneal limbal stem cells (LSCs) during wound healing. This research addresses corneal damage, a leading cause of blindness affecting over 11 million individuals worldwide, by investigating the mechanisms through which injury impacts the limbal...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
The University of Cincinnati received a $445,500 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded June 1, 2026, with a completion date of May 31, 2028. The project, titled "Fate Mapping and Functional Analysis of COL8A2-Positive Cells in Corneal Endothelial Development and Disease," will deliver fundamental research findings on the developmental origins and functional contributions of COL8A2-positive cells to corneal endothelial development and maintenance. The research addresses a critical knowledge gap regarding why mutations in the COL8A2 gene, which encodes a key extracellular matrix component of Descemet membrane, disproportionately affect the corneal endothelium and cause Fuchs endothelial corneal dystrophy (FECD) and related disorders. The grant will produce two primary research deliverables through lineage tracing and cell ablation studies using a newly developed transgenic mouse model (COL8A2P2A-CREERT2). These studies will establish the lineage relationship and functional necessity of COL8A2-positive cells for corneal endothelial formation and maintenance, with outcomes including characterization of endothelial morphology, cell density changes, and Descemet membrane structure. The research findings will advance fundamental understanding of endothelial biology and inform the development of regenerative treatment strategies for endothelial dystrophies, contributing directly to NEI's mission of driving innovative research to prevent and treat vision diseases.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $445.5k | 6/5/26 |