Project Grant K99EY037847
- The National Eye Institute (NEI) awarded a $448,250 project grant under their Vision Research federal grant program (CFDA 93.867) to The Research Foundation for the State University of New York, operating as Upstate Medical Center. The funding supports a 2-year research project titled "YKI-MITF-ECM Regulation of Eye Progenitor Epithelium Morphology" that will explore the role of the Hippo signaling pathway, the transcription factor MITF, and extracellular matrix in the development...
- This $148,568 Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), supports research at Emory University to investigate the role of scleral fibroblasts in refractive development and myopia. The primary objectives are to: 1) Identify characteristics of scleral fibroblasts in mouse eyes that undergo normal refractive development versus those exposed to myopic stimuli, and 2) Determine the role of retinoic acid signaling in driving...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $586,258 project grant to Wayne State University to characterize the role of eosinophils in modulating the corneal response to Pseudomonas aeruginosa-induced infection. The 4-year project, commencing on July 1, 2025 and completing on April 30, 2029, aims to investigate the spatiotemporal distribution, phenotypic profiles, and proteomic changes of eosinophils during corneal infection. The...
- This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $450,300 to support research aimed at understanding how corneal limbal stem cells function during wound healing. The project, being conducted by The Regents of the University of California, San Francisco (UCSF), seeks to advance the understanding of limbal stem cell populations and their role in maintaining corneal homeostasis and enabling corneal wound repair. This...
- This federal Project Grant award of $243,000 from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), supports research to understand the role of the protein SMAD4 in regulating the extracellular matrix homeostasis of the corneal stroma. The research aims to elucidate how SMAD4 controls both the synthesis and degradation of the corneal extracellular matrix, which is critical for corneal stromal morphogenesis and homeostasis. The project, led by researchers at the...
- This federal Project Grant award of $143,569 was provided by the National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), to the Rochester Institute of Technology (RIT) from July 1, 2025 to June 30, 2029. The goal of the research is to establish the molecular-level understanding of the phase diagram and liquid structure of concentrated eye lens protein mixtures, which is critical for addressing the leading cause of blindness worldwide - cataract disease. The research will...
- This federal Project Grant award of $104,012.00 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) is supporting research by Drexel University to characterize visual feature encoding in Drosophila melanogaster (fruit fly) visual projection neurons LPLC1 and LPLC2. The goal is to uncover the selectivity of these neurons to specific visual features and understand the underlying mechanisms governing their feature encoding. The 2-year project period runs from...
- This $237,996 Project Grant from the National Eye Institute (CFDA 93.867 Vision Research program) aims to investigate advanced approaches for high-resolution in-vivo imaging of the cornea. The award to the University of Colorado will develop a speckle illumination holographic imaging technique that can capture wide field-of-view, 3D information about corneal structures with polarization-sensitive detection. After optimization, the system will be validated through in-vivo testing in healthy human...
- This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), aims to investigate the role of small MAF transcription factors and their co-regulators in controlling gene expression and development of the eye lens. The $386,676 award to the University of Delaware will support research to characterize mouse models with genetic knockout of the MAFG, MAFK, and NRF2 genes, and use advanced genomic techniques to identify their direct targets...
- This $332,179 Project Grant awarded by the National Eye Institute (CFDA 93.867 Vision Research) supports the development of nanobarrier contact lenses that can provide sustained delivery of the drug cysteamine to treat the ocular complications of cystinosis. The lenses are designed to replace the current 8-times daily eye drop regimen, improving patient compliance and reducing side effects from the preservatives and acidic pH in the eye drops. The project aims to demonstrate the lenses can...
This federal Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) is supporting research at New York University (NYU) to investigate the mechanism of corneal lens development in the Drosophila model organism. The $142,749 award, spanning September 2025 to August 2027, aims to use genetic, microscopy, and transcriptomic approaches to study the role of the polysaccharide chitin and the central and lattice cells of the fly corneal lens in determining its curved refractive shape. This research could provide insights into preventing or treating human corneal disorders like myopia, hyperopia, astigmatism, and keratoconus. As a leading academic medical center, NYU has demonstrated extensive capabilities in delivering complex vision science research to federal agencies like the NEI.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $142.7k | 9/8/25 |