Project Grant R01AG096039
- This federal Project Grant award of $3,230,150.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at the University of Kansas Center for Research Inc. investigating the relationship between neuronal activity, synaptic abnormalities, and mitochondrial function in Alzheimer's disease. The study aims to determine whether modulating these factors could enhance neural plasticity in amyloidosis using mouse models. Through a combination of in vivo and ex vivo...
- This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) provides $759,352 to investigate how shifts in microglial metabolism impact the progression of Alzheimer's disease (AD) and whether targeting metabolic flux can reduce AD-related pathology. The research aims to elucidate the role of lactate, a byproduct of glycolysis, in regulating immunometabolism and microglial activity in the context of AD. The 5-year award, starting on May 15,...
- This Project Grant award from the National Institutes of Health (NIH), under the Aging Research program (CFDA 93.866), provides $610,836 to The Broad Institute, Inc. to conduct research on mitonuclear interactions in aging and neurodegenerative diseases like Alzheimer's. The project aims to leverage recent technological advances, including mitochondrial DNA editing and large-scale biobank analyses, to systematically investigate how mitonuclear interactions contribute to aging and...
- This Project Grant award, with a total funding amount of $878,190.00, was provided by the National Institute on Aging (part of the U.S. Department of Health and Human Services) under the Aging Research federal grant program (CFDA 93.866). The grant is supporting research by the Scripps Research Institute in California to investigate a "druggable mito-nuclear feedback mechanism" that can preserve mitochondrial and synaptic function in aging and age-related dementias like Alzheimer's...
- This Project Grant award for $466,125, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to analyze the effects of Alzheimer's disease on subcellular transcriptome dynamics and mitonuclear coordination in neuronal soma and projections. The research, conducted by Harvard Medical School, will use a novel technique called Subcellular Timelapse-Seq (STL-Seq) to simultaneously quantify the kinetic rates of transcription, nuclear export, ribosome...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $781,008.00 to investigate the role of tRNA modifications in regulating mitochondrial function and the mitochondrial proteome in Alzheimer's disease and related disorders (AD/ADRD). The research aims to identify genetic mutations in mitochondrial DNA, tRNA genes, and genes encoding the mitochondrial proteome that are associated with AD status, using large-scale whole genome sequencing data from...
- This Project Grant award of $328,000 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports the Alzheimer's Disease Organelle Proteome Task (ADOPT) pilot phase. The interdisciplinary research team, led by Drs. Biao Wang and Danielle Swaney at the University of California, San Francisco, will use a genetic organelle tagging approach to rapidly purify lysosomes from neurons in wild-type and Alzheimer's disease mouse models. A suite of mass spectrometry experiments will then...
- This federal Project Grant award of $839,933 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate the role of N6-methyladenosine (m6A) RNA modifications in microglial dysfunction and Alzheimer's disease (AD) pathogenesis. The project aims to systematically map m6A modification landscapes in microglia isolated from human brain tissue and human induced pluripotent stem cell-derived microglial models. The researchers will also use CRISPR-based...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $308,000 to the Regents of the University of Minnesota to investigate the impact of amyloid-beta 42 (Aβ42) on mitochondrial liquid-liquid phase separation and its effects on mitochondrial dysfunction in Alzheimer's disease. The primary goals are to: (1) Investigate the impact of Aβ42 on mitochondrial ribonucleoprotein granule dynamics in mitochondria; and (2) Use optogenetic control of Aβ42...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $638,682 project grant under the Aging Research Federal Grant Program (CFDA 93.866) to the University of Arizona on August 1, 2025. The project, titled "TDP-43 LLPS and Mitochondrial Dysfunction in Neurodegeneration", aims to investigate the relationship between the liquid-liquid phase separation (LLPS) of the TDP-43 protein and mitochondrial dysfunction in neurodegenerative...
This $555,501 Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI). The overarching goal of the project is to investigate the hypothesis that mitochondrial dysfunction in Alzheimer's disease (AD) leads to increased glycolysis and elevated lactate production, which induces lactylation of histones and non-histone proteins. This post-translational modification is expected to result in structural and functional nuclear damage, epigenetic alterations, and dysregulation of gene expression in AD pathogenesis. The specific aims are to: 1) Investigate the effects of non-histone protein lactylation on nuclear structure and functions through tau, 2) Investigate epigenetic changes through histone lactylation in AD, and 3) Characterize the effects of AD-patient-derived mitochondrial dysfunction in inducing both histone and non-histone protein lactylation through increased glycolysis. This research project is expected to establish novel diagnostic and therapeutic targets against AD by focusing on lactylated histone and non-histone proteins.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $555.5k | 9/8/25 |