Project Grant R03AG091095
Award Date
1/1/25
Completion Date
12/31/26
Dollars Obligated
$328K
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
San Francisco, CA 94143, USA
Similar Awards
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $663,376 to The Regents of the University of California, San Francisco to explore the molecular mechanisms underlying the heterogeneity of Alzheimer's disease and related dementias. The project aims to identify key genes that mediate the selective vulnerability of brain regions to distinct pathological protein conformers, such as tau and alpha-synuclein, using a novel computational modeling...
This $15,046,454 project grant from the National Institutes of Health National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research at the University of California, San Diego to improve understanding of proteomic changes preceding Alzheimer's disease and related dementias. The research will analyze longitudinal plasma samples from 2,836 women in the Women's Health Initiative Memory Study cohort using the Somamscan proteomics platform to identify novel...
This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
This Project Grant award of $816,661 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a comprehensive research project entitled "Aberrant Proteomes in Tauopathy: Revealing Functional Consequences via Multimodal Proteomics". The research, conducted by The Regents of the University of California, San Francisco, aims to systematically elucidate the molecular and cellular mechanisms by which pathological tau drives neurodegeneration in Alzheimer's disease...
This $3,841,367 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports research to better understand the role of the TBK1 protein kinase and associated autophagy pathways in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The University of California, San Francisco (UCSF) will use advanced stem cell models and proteomics to: 1) identify novel TBK1 substrates and characterize the effects of TBK1 loss on...
This $605,486 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports research to define the mechanisms that coordinate late endosome and lysosome functions in neurons. The research aims to address the significant lack of understanding about how the network of proteins that control lysosome function is integrated to meet the unique demands of neurons. This is a critical barrier to understanding the relevance of abnormal lysosome...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,286,635 to the University of California, San Diego (UCSD) to investigate the role of microglial BIN1 in Alzheimer's disease pathogenesis. The project aims to identify the downstream pathways and mediators of microglial BIN1, examine the effect of reduced microglial BIN1 expression on the onset and progression of tauopathy, and assess the in vivo role of microglial BIN1 in a murine model of...
This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $784,596 to Northeastern University to conduct comprehensive and cell type-specific proteogenomic profiling of aberrant and mis-processed proteins in Alzheimer's disease (AD) and tauopathy models. The project aims to substantially expand understanding of protein dysfunctions in AD by applying state-of-the-art proteomic methods paired with proteogenomics across multiple brain regions, AD stages,...
This Project Grant award of $628,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate how Alzheimer's disease (AD) pathogenesis interferes with synaptic autophagy and whether targeting synaptic autophagy can be neuroprotective in an AD mouse model. The research will utilize primary hippocampal cell cultures and mouse models to determine which steps in the autophagic processing of synaptic proteins are disrupted by AD, and evaluate if overexpressing the...