This $2,119,771 Project Grant award from the National Institute on Aging (under CFDA 93.866 - Aging Research) will fund research at the University of Massachusetts Medical School (UMass Medical) to investigate the role of peripheral insulin resistance and inflammation in Alzheimer's disease (AD) pathogenesis. The project aims to define age-related changes in metabolism and inflammation in peripheral organs, particularly the liver, and examine how these processes impact AD-relevant...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,241,676 to The University of Iowa to investigate the role of glycolysis, a key glucose metabolism process, in rodent models of Alzheimer's disease. The project aims to interrogate how disruptions in glycolysis affect neurodegeneration in Alzheimer's disease models, and whether enhancing glycolysis can mitigate neurodegeneration. The research will utilize advanced imaging techniques,...
This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $660,402 to the University of Maryland, Baltimore (UMB) to study the role of autophagy, a cellular process that recycles damaged components, in regulating lipid metabolism and inflammation in microglia during brain aging and neurodegenerative diseases like Alzheimer's disease (AD). The research aims to determine how microglial lipid phagocytosis inhibits autophagy, leading to the...
This Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $812,030 to The Trustees of the University of Pennsylvania to develop and optimize noninvasive imaging biomarkers to track neuroinflammation in the early stages of Alzheimer's disease (AD). The research aims to explore the connections between neuroinflammation, brain glucose hypometabolism, and AD progression using advanced magnetic resonance imaging techniques like...
This $745,765 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) in New York aims to investigate the effects of Alzheimer's disease (AD) risk genes and aging on human microglia activity and lipid metabolism. The key focus is on understanding how genetic variants associated with increased AD risk or longevity may impact microglia's ability to clear cholesterol/lipid-rich cellular debris, a critical...
The Project Grant award for "NEURODEGENERATIVE REPROGRAMING OF MICROGLIA IN ALZHEIMER'S DISEASE" was provided by the National Institute on Aging (CFDA 93.866 Aging Research) in the amount of $442,357.00. The grant, awarded to the Research Foundation of the City University of New York (RFCUNY), aims to elucidate the molecular mechanisms underlying a specific subset of stressed "dark" microglia and their neurodegenerative impact in Alzheimer's disease (AD) models. The...
The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded a $1,684,689 project grant to Weill Medical College of Cornell University to study the role of microglial lysosomes in the degradation of amyloid-beta, a key pathological feature of Alzheimer's disease. The 3-year project aims to characterize the process of "digestive exophagy" used by microglia to limit the expansion of amyloid-beta plaques, as well as explore the effects of genetic...
This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
This federal Project Grant award, funded by the National Institute on Aging (CFDA 93.866 - Aging Research), provides $6,226,692 to The Trustees of Columbia University in the City of New York to conduct research on the role of neuronal hyperexcitability and proteostasis (protein homeostasis) in the progression of Alzheimer's disease. The research aims to identify key early events in Alzheimer's disease pathology, particularly in the locus coeruleus and hippocampus regions of the brain, and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the J. David Gladstone Institutes is focused on exploring the role of the NOX2 enzyme in mediating brain dysfunction associated with Alzheimer's disease (AD). The $842,175 award, spanning December 2024 to November 2029, aims to investigate how inhibiting NOX2 could mitigate AD-related pathologies such as amyloid-beta and tau protein accumulation, network hyperactivity, glucose...