Project Grant R01AG087952

Award Date 8/1/25
Completion Date 5/31/30
Dollars Obligated $639K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Arizona, USA
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $308,000 to the Regents of the University of Minnesota to investigate the impact of amyloid-beta 42 (Aβ42) on mitochondrial liquid-liquid phase separation and its effects on mitochondrial dysfunction in Alzheimer's disease. The primary goals are to: (1) Investigate the impact of Aβ42 on mitochondrial ribonucleoprotein granule dynamics in mitochondria; and (2) Use optogenetic control of Aβ42...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Case Western Reserve University provides $442,750 to develop synthetic replicas of TDP-43 protein filaments associated with frontotemporal dementia and amyotrophic lateral sclerosis. The goal is to establish in vitro conditions for generating amyloid fibrils with structures identical to brain-derived TDP-43 filaments, which would enable mechanistic studies on disease-relevant aggregation pathways...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $460,625.00 to the University of Massachusetts Medical School (UMass Medical) from June 1, 2025 to May 31, 2027. The grant supports research to investigate the role of TDP-43 citrullination in the pathogenesis of amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The...
This Project Grant award of $672,894, issued on September 15, 2024 by the National Institute on Aging (CFDA 93.866 - Aging Research), is funding research to investigate the interaction between TDP-43 proteinopathy and hippocampal sclerosis in Alzheimer's disease. The primary awardee, the University of Utah, will quantitatively analyze the distributions of a novel TDP-43 species and neuronal loss in Alzheimer's disease hippocampi (Aim 1). They will also use spatial sequencing technologies to...
This Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,275,512 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the impact of progranulin species on TDP-43 proteolysis and pathobiology in neurodegenerative disorders such as Alzheimer's disease, frontotemporal dementia, and limbic-predominant, age-associated TDP-43 encephalopathy. The research aims to determine how progranulin species contribute to TDP-43...
The National Institutes of Health's National Institute on Aging awarded the University of Wyoming a $4,510,756 project grant under the Aging Research program (CFDA 93.866) to investigate the impact of TAR DNA-binding protein 43 (TDP-43) loss on prefrontal neural activity and circuitry. The three-year award beginning September 2022 will support research using mouse models, human pluripotent stem cell-derived cortical neurons, and patient brain tissues to determine how TDP-43 loss leads to...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is supporting research to investigate the role of the deubiquitylation pathway in TDP-43 pathology associated with Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). The $460,625 award, with a project period from June 7, 2025 to May 31, 2027, will enable the University...
The National Institute on Aging awarded Case Western Reserve University $1,785,220 under the Aging Research program (CFDA 93.866) from May 2022 to April 2025. The university will research the role of deubiquitinase USP19 in the pathogenesis of TDP-43, a protein implicated in neurodegenerative diseases like frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Using mouse models, human post-mortem tissues, and molecular and cell biology techniques, the university aims to validate...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will provide $3,727,176 to the University of North Carolina at Chapel Hill to study how environmental toxicants impact the development of TDP-43 proteinopathies, a hallmark of neurodegenerative disorders like frontotemporal dementia and amyotrophic lateral sclerosis. The research team will conduct in vivo and neuronal model experiments to evaluate the pathophysiological relevance of toxicant exposure,...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $757,027 to the University of Washington to conduct research on the synergistic relationship between tau and TDP-43 proteins in Alzheimer's disease. The research aims to identify mechanisms that drive the interaction between these two pathological hallmarks of Alzheimer's and how they contribute to cognitive decline and neurodegeneration. Key activities include using C. elegans models to...

This Project Grant award of $638,682 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), supports research to investigate the role of liquid-liquid phase separation (LLPS) of the TDP-43 protein and its interactions with mitochondria in neurodegenerative diseases.

The research aims to systematically examine how LLPS regulates TDP-43 localization to mitochondria, and how this contributes to TDP-43-induced mitochondrial dysfunction and neuronal loss, using multiple cell and animal models. The findings are expected to enhance the understanding of the intricate mechanisms underlying a broad spectrum of neurodegenerative diseases, including amyotrophic lateral sclerosis, frontotemporal dementia, Alzheimer's disease, and related dementias, where TDP-43 proteinopathy is a prominent pathological hallmark. The award was granted to the University of Arizona and is set to run from August 1, 2025 through May 31, 2030.

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