The National Institute on Aging (NIA), through its Aging Research federal grant program (CFDA 93.866), has awarded a $308,000 Project Grant to the Regents of the University of Minnesota to investigate the impact of amyloid-beta (Aβ42) on mitochondrial liquid-liquid phase separation and its implications for Alzheimer's disease. The overarching goal is to identify the mechanisms by which Aβ42 interferes with mitochondrial gene expression regulation and contributes to mitochondrial dysfunction in Alzheimer's disease. The University of Minnesota research team will pursue two specific aims: (1) Investigate the impact of Aβ42 on mitochondrial ribonucleoprotein granule dynamics, and (2) Utilize optogenetic control to study the relationship between Aβ42 and mitochondrial ribonucleoprotein granules. This project will provide insights into maintaining mitochondrial health by modulating liquid-liquid phase separation in the context of Alzheimer's disease.
Generated 2/25/25, 3:05 AM