Project Grant R01AG096052
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), provides $848,993.00 to examine tRNA modifications in Alzheimer's disease and related dementias (ADRD). The research aims to investigate how changes in the tRNA epitranscriptome and tRNA translation dynamics contribute to protein misfolding and proteotoxic stress in ADRD. The project will run from September 15, 2025 to May 31, 2030 and is being conducted by the...
- This Project Grant award for $466,125, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to analyze the effects of Alzheimer's disease on subcellular transcriptome dynamics and mitonuclear coordination in neuronal soma and projections. The research, conducted by Harvard Medical School, will use a novel technique called Subcellular Timelapse-Seq (STL-Seq) to simultaneously quantify the kinetic rates of transcription, nuclear export, ribosome...
- This Project Grant award from the National Institutes of Health (NIH), under the Aging Research program (CFDA 93.866), provides $610,836 to The Broad Institute, Inc. to conduct research on mitonuclear interactions in aging and neurodegenerative diseases like Alzheimer's. The project aims to leverage recent technological advances, including mitochondrial DNA editing and large-scale biobank analyses, to systematically investigate how mitonuclear interactions contribute to aging and...
- This $784,596 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Northeastern University supports comprehensive proteogenomic profiling of aberrant and mis-processed proteins in Alzheimer's disease and tauopathy models. The project aims to develop a proteogenomic pipeline to globally characterize disease-associated proteins with amino acid substitutions, alternative isoforms, post-translational modifications, and proteolytic cleavages across multiple brain...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $308,000 to the Regents of the University of Minnesota to investigate the impact of amyloid-beta 42 (Aβ42) on mitochondrial liquid-liquid phase separation and its effects on mitochondrial dysfunction in Alzheimer's disease. The primary goals are to: (1) Investigate the impact of Aβ42 on mitochondrial ribonucleoprotein granule dynamics in mitochondria; and (2) Use optogenetic control of Aβ42...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $848,286 to the University of South Florida to conduct research on the role of N6-methyladenosine (m6A) RNA modifications in Alzheimer's disease (AD). The key objectives are to: 1) Create a high-resolution map of m6A sites in the brains of older adults, 2) Identify specific m6A alterations associated with AD and its clinical/pathological features, and 3) Elucidate how m6A dysregulation may...
- This Project Grant award from the National Institutes of Health's Aging Research program (CFDA 93.866) will support research to identify early transcriptional and pathological changes in brain regions vulnerable to Alzheimer's disease (AD). The $459,076 award, granted to Trustees of Boston University, will use single-nucleus RNA sequencing and targeted mass spectrometry to profile cell type-specific gene expression and tau/amyloid beta proteoforms in the transentorhinal cortex, entorhinal...
- This Project Grant award for $472,073, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports a research project at The Trustees of Columbia University in the City of New York to investigate the role of post-translational modifications, specifically sumoylation and succinylation, in the mitochondrial-nuclear communication mechanisms underlying tau toxicity in frontotemporal dementia (FTD). The project aims to elucidate how changes in these modifications influence...
- This $816,661 Project Grant award, issued on June 1, 2025 by the National Institute on Aging (CFDA 93.866 Aging Research program), supports comprehensive research aimed at elucidating the molecular mechanisms underlying tauopathies such as Alzheimer's disease and frontotemporal dementia. The project, titled "Aberrant Proteomes in Tauopathy: Revealing Functional Consequences via Multimodal Proteomics", combines expertise in mass spectrometry-based proteomics and functional genomics to...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $638,682 project grant under the Aging Research Federal Grant Program (CFDA 93.866) to the University of Arizona on August 1, 2025. The project, titled "TDP-43 LLPS and Mitochondrial Dysfunction in Neurodegeneration", aims to investigate the relationship between the liquid-liquid phase separation (LLPS) of the TDP-43 protein and mitochondrial dysfunction in neurodegenerative...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $781,008.00 to investigate the role of tRNA modifications in regulating mitochondrial function and the mitochondrial proteome in Alzheimer's disease and related disorders (AD/ADRD). The research aims to identify genetic mutations in mitochondrial DNA, tRNA genes, and genes encoding the mitochondrial proteome that are associated with AD status, using large-scale whole genome sequencing data from the Alzheimer's Disease Sequencing Project (ADSP). The award was made to the Trustees of Boston University, doing business as the Boston University Medical Campus, a prominent private research institution in Massachusetts. The project will run from September 15, 2025 to June 30, 2030, advancing scientific understanding of the mitochondrial-nuclear crosstalk underlying age-related neurodegeneration in AD/ADRD.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $781.0k | 9/8/25 |