Project Grant RF1AG091421
- This $555,501 Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI). The overarching goal of the project is to investigate the hypothesis that mitochondrial dysfunction in Alzheimer's disease (AD) leads to increased glycolysis and elevated lactate production, which induces lactylation of histones and non-histone proteins. This...
- This federal Project Grant award of $2,602,940 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research conducted by the Oklahoma Medical Research Foundation (OMRF) to investigate the role of mitochondrial AMPK signaling in neurons and its impact on dendritic spine maintenance. The research aims to determine the molecular composition and dynamics of mitochondrial-localized AMPK complexes (mitoAMPK) in Alzheimer's disease (AD) neurons, as well as establish mitoAMPK's...
- This federal Project Grant award of $3,221,450.00 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to define how neuronal hyperexcitability in the retrosplenial cortex (RSC) contributes to the development of Alzheimer's disease (AD)-related behavioral deficits in mouse models. The research aims to determine the effect of inhibiting RSC layer 5 cells on spatial memory and navigation, as well as when hyperexcitability emerges in these cells across different AD...
- This Project Grant award from the National Institutes of Health (NIH), under the Aging Research program (CFDA 93.866), provides $610,836 to The Broad Institute, Inc. to conduct research on mitonuclear interactions in aging and neurodegenerative diseases like Alzheimer's. The project aims to leverage recent technological advances, including mitochondrial DNA editing and large-scale biobank analyses, to systematically investigate how mitonuclear interactions contribute to aging and...
- This Project Grant award, with a total funding amount of $878,190.00, was provided by the National Institute on Aging (part of the U.S. Department of Health and Human Services) under the Aging Research federal grant program (CFDA 93.866). The grant is supporting research by the Scripps Research Institute in California to investigate a "druggable mito-nuclear feedback mechanism" that can preserve mitochondrial and synaptic function in aging and age-related dementias like Alzheimer's...
- This federal Project Grant award of $839,933 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate the role of N6-methyladenosine (m6A) RNA modifications in microglial dysfunction and Alzheimer's disease (AD) pathogenesis. The project aims to systematically map m6A modification landscapes in microglia isolated from human brain tissue and human induced pluripotent stem cell-derived microglial models. The researchers will also use CRISPR-based...
- This federal Project Grant award of $2,631,670 from the National Institute on Aging (CFDA 93.866 Aging Research) supports a research initiative at The Washington University to investigate age-related deficits in episodic memory. The project aims to determine how aging distinctly affects the content and structure of memory representations, and how this relates to dysfunction in different brain networks based on susceptibility to Alzheimer's disease pathology. The research will utilize plasma...
- This Project Grant award for $466,125, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to analyze the effects of Alzheimer's disease on subcellular transcriptome dynamics and mitonuclear coordination in neuronal soma and projections. The research, conducted by Harvard Medical School, will use a novel technique called Subcellular Timelapse-Seq (STL-Seq) to simultaneously quantify the kinetic rates of transcription, nuclear export, ribosome...
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate physiological pathways that modulate the regulation of the tau protein, which is associated with neurodegenerative diseases like Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). The research is being conducted by the Johns Hopkins University and aims to better understand how disruptions in the signaling pathway involving the enzyme GDE2 lead to...
- This federal Project Grant award of $2,316,710 from the National Institute on Aging (CFDA 93.866 Aging Research) aims to develop magnetogenetic techniques for manipulating the activity of specific brain cell types implicated in the onset and progression of Alzheimer's disease (AD). The research will focus on using a magnetogenetic tool called FERIC (Ferritin Iron Redistribution to Ion Channels) in combination with enhancer AAV vectors to non-invasively control the activity of AD-vulnerable...
This federal Project Grant award of $3,230,150.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at the University of Kansas Center for Research Inc. investigating the relationship between neuronal activity, synaptic abnormalities, and mitochondrial function in Alzheimer's disease. The study aims to determine whether modulating these factors could enhance neural plasticity in amyloidosis using mouse models. Through a combination of in vivo and ex vivo approaches, the research seeks to unravel the connections between neural activity and synaptic deficits, as well as test the efficacy of targeting the mitochondrial membrane permeability transition pore component cyclophilin D in improving mitochondrial health and reversing synaptic and neural activity impairments. The award period runs from Sep 30, 2025 to Aug 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.2m | 9/24/25 |