This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,516,316.00 to the President and Fellows of Harvard College, Office of Research Administration (Harvard Medical School) to conduct research on "Neuronal Activity-Responsive DNA Repair Mechanisms and Cognitive Aging." The project aims to investigate the relationship between neuronal activity, DNA damage repair, and cognitive decline associated with Alzheimer's disease and normal...
This $705,775 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to map mitochondrial diversity in the aging brain and immune system. The goal is to establish cell type-specific mitochondrial recalibrations associated with age, cognition, and Alzheimer's disease (AD).
The research will leverage a novel computational "mitotyping" approach to profile mitochondrial biology at single-cell resolution in over 1.4 million brain...
This Project Grant award for $391,668 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at the University of California, San Diego (UCSD) to investigate the role of mRNA localization and co-translational protein targeting in driving mitochondrial dysfunction in neurodegenerative diseases. The 2-year project seeks to: 1) quantify heterogeneity in mitochondrial protein expression across different mitochondrial morphologies induced by Alzheimer's and...
This federal Project Grant award, valued at $728,406.00 and administered by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), supports research to identify transcription factors that regulate the expression of the MAPT gene, which is associated with neurodegenerative diseases like Alzheimer's.
The key objectives are to: (1) use CRISPR screens to find transcription factors that can modulate MAPT transcription, (2) determine which trans-regulatory elements...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) will provide $2,413,601.00 in funding from June 2024 to May 2027 to investigate the role of extracellular vesicles, particularly mitovesicles of mitochondrial origin, in Alzheimer's disease pathology.
The research aims to characterize the biology and function of mitovesicles in the brain, including their generation, secretion, transport, and uptake by different cell types. It...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the impact of amyloid-beta 42 (Aβ42) on mitochondrial liquid-liquid phase separation and mitochondrial dysfunction in Alzheimer's disease. The $308,000 award to the Regents of the University of Minnesota will pursue two specific aims: (1) examining the effects of Aβ42 on mitochondrial ribonucleoprotein granule dynamics, and (2) using optogenetic control to study the relationship...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), seeks to develop a statistical framework for understanding the genetic landscape of Alzheimer's disease and related dementias (AD/ADRD). The $2,201,136 award to The Trustees of Columbia University will leverage large-scale biobanks and electronic medical records to study the age-dependent genetic architecture and cross-phenotype dependencies of AD/ADRD across diverse...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) provides $835,825 to the University of Massachusetts Medical School to conduct research on somatic mutations in Alzheimer's disease. The project aims to analyze patterns of somatic single nucleotide variants, short insertions/deletions, and structural variants in neurons from Alzheimer's disease brains across disease progression. It will also examine how these...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $239,122 to Yale University to leverage computational and experimental models to study the impact of aging processes and Alzheimer's disease (AD) risk variants on brain function. The key objectives are to:
Develop a cell-type specific regulatory network model for normal brain aging and AD brain aging, integrating large-scale epigenomic and transcriptomic datasets.
Generate empirical data...