Project Grant R01AG095944
- This Project Grant award for $466,125, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to analyze the effects of Alzheimer's disease on subcellular transcriptome dynamics and mitonuclear coordination in neuronal soma and projections. The research, conducted by Harvard Medical School, will use a novel technique called Subcellular Timelapse-Seq (STL-Seq) to simultaneously quantify the kinetic rates of transcription, nuclear export, ribosome...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $793,777 to the J. David Gladstone Institutes to conduct research on the impact of mitochondrial genome architecture on the accumulation of somatic mitochondrial DNA (mtDNA) mutations over an individual's lifetime. The primary goal is to understand how mtDNA compaction influences mutation rates and mitochondrial health, with potential implications for the prevention and treatment of...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $781,008.00 to investigate the role of tRNA modifications in regulating mitochondrial function and the mitochondrial proteome in Alzheimer's disease and related disorders (AD/ADRD). The research aims to identify genetic mutations in mitochondrial DNA, tRNA genes, and genes encoding the mitochondrial proteome that are associated with AD status, using large-scale whole genome sequencing data from...
- This Project Grant award, with a total funding amount of $878,190.00, was provided by the National Institute on Aging (part of the U.S. Department of Health and Human Services) under the Aging Research federal grant program (CFDA 93.866). The grant is supporting research by the Scripps Research Institute in California to investigate a "druggable mito-nuclear feedback mechanism" that can preserve mitochondrial and synaptic function in aging and age-related dementias like Alzheimer's...
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the University of Southern California to investigate methods for purging mammalian cells of deleterious mutations in the mitochondrial genome (mtDNA) that contribute to aging and age-related diseases. The research aims to develop new genetic and molecular biology tools, combined with advanced sequencing techniques, to selectively remove harmful mtDNA mutations from...
- This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $2,173,794 to The General Hospital Corporation (Massachusetts General Hospital) to conduct research on enhancing brain resilience to Alzheimer's disease by targeting adult hippocampal neurogenesis. The project aims to explore the mechanisms by which adult hippocampal neurogenesis cooperates with brain-derived neurotrophic factor (BDNF) to potentially slow cognitive decline in...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $399,766 to the University of Kansas Center for Research Inc. and the University of California, Santa Barbara to conduct research on understanding the interplay between mitochondrial and nuclear genomes and their impact on mitochondrial dysfunction and age-related diseases. The key focus is leveraging the mitochondrial genomic variation observed in populations of threespine stickleback fish to...
- The National Institute on Aging (NIA) awarded a $157,998 Project Grant to The Medical University of South Carolina (MUSC) on July 17, 2025 under the Aging Research federal grant program (CFDA 93.866). The grant supports research to investigate the role of ceramides, a class of bioactive lipids, in regulating mitophagy (the recycling of damaged mitochondria) and its potential therapeutic applications for Alzheimer's disease. The research aims to elucidate the intricate mechanisms by which...
- This federal Project Grant award of $839,933 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate the role of N6-methyladenosine (m6A) RNA modifications in microglial dysfunction and Alzheimer's disease (AD) pathogenesis. The project aims to systematically map m6A modification landscapes in microglia isolated from human brain tissue and human induced pluripotent stem cell-derived microglial models. The researchers will also use CRISPR-based...
- This $6,925,230 Project Grant award from the National Institutes of Health (NIH) National Institute on Aging (CFDA 93.866 - Aging Research) will support a research project at The Trustees of Columbia University in the City of New York to develop a "Multi-Organ Chart of Personalized Susceptibility to Alzheimer's Disease and Aging." The overarching goal is to use large-scale multi-omics, multi-organ biomedical data, advanced artificial intelligence/machine learning, and computational...
This Project Grant award from the National Institutes of Health (NIH), under the Aging Research program (CFDA 93.866), provides $610,836 to The Broad Institute, Inc. to conduct research on mitonuclear interactions in aging and neurodegenerative diseases like Alzheimer's. The project aims to leverage recent technological advances, including mitochondrial DNA editing and large-scale biobank analyses, to systematically investigate how mitonuclear interactions contribute to aging and age-associated disorders. The research will focus on generating an experimentally validated inventory of nuclear genes and proteins that control mitochondrial DNA copy number, with the goal of advancing scientific understanding of the underlying mechanisms involved in age-related mitochondrial alterations and their potential causal links to Alzheimer's disease and related dementias. The award period runs from September 1, 2025 to May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $610.8k | 8/27/25 |