Project Grant R01AG095974
- This Project Grant award from the National Institutes of Health (NIH), under the Aging Research program (CFDA 93.866), provides $610,836 to The Broad Institute, Inc. to conduct research on mitonuclear interactions in aging and neurodegenerative diseases like Alzheimer's. The project aims to leverage recent technological advances, including mitochondrial DNA editing and large-scale biobank analyses, to systematically investigate how mitonuclear interactions contribute to aging and...
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the University of Southern California to investigate methods for purging mammalian cells of deleterious mutations in the mitochondrial genome (mtDNA) that contribute to aging and age-related diseases. The research aims to develop new genetic and molecular biology tools, combined with advanced sequencing techniques, to selectively remove harmful mtDNA mutations from...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $638,682 project grant under the Aging Research Federal Grant Program (CFDA 93.866) to the University of Arizona on August 1, 2025. The project, titled "TDP-43 LLPS and Mitochondrial Dysfunction in Neurodegeneration", aims to investigate the relationship between the liquid-liquid phase separation (LLPS) of the TDP-43 protein and mitochondrial dysfunction in neurodegenerative...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $793,777 to the J. David Gladstone Institutes to conduct research on the impact of mitochondrial genome architecture on the accumulation of somatic mitochondrial DNA (mtDNA) mutations over an individual's lifetime. The primary goal is to understand how mtDNA compaction influences mutation rates and mitochondrial health, with potential implications for the prevention and treatment of...
- The National Institute on Aging (NIA) awarded a $1,459,072 project grant to the J. David Gladstone Institutes under the Aging Research Federal Grant Program (CFDA 93.866) to monitor and manipulate inhibitory interneuron cell populations in mouse models of Alzheimer's disease. The 2-year project aims to use dual cell-type-specific enhancer-associated adeno-associated viruses (enhancer-AAVs) to independently monitor and control parvalbumin (PVALB) and somatostatin (SST) inhibitory interneurons...
- This federal Project Grant award of $2,602,940 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research conducted by the Oklahoma Medical Research Foundation (OMRF) to investigate the role of mitochondrial AMPK signaling in neurons and its impact on dendritic spine maintenance. The research aims to determine the molecular composition and dynamics of mitochondrial-localized AMPK complexes (mitoAMPK) in Alzheimer's disease (AD) neurons, as well as establish mitoAMPK's...
- This Project Grant award for $466,125, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to analyze the effects of Alzheimer's disease on subcellular transcriptome dynamics and mitonuclear coordination in neuronal soma and projections. The research, conducted by Harvard Medical School, will use a novel technique called Subcellular Timelapse-Seq (STL-Seq) to simultaneously quantify the kinetic rates of transcription, nuclear export, ribosome...
- This federal Project Grant award of $3,230,150.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at the University of Kansas Center for Research Inc. investigating the relationship between neuronal activity, synaptic abnormalities, and mitochondrial function in Alzheimer's disease. The study aims to determine whether modulating these factors could enhance neural plasticity in amyloidosis using mouse models. Through a combination of in vivo and ex vivo...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $126,956.00 to the University of California, San Diego (UCSD) to conduct research on identifying mechanisms of adult neurogenesis in the aging brain. The key objectives of this project are to: Utilize single cell spatial transcriptomics to define the pathways of generating new neurons in aged neurogenic niches following transient, antisense oligonucleotide-mediated suppression of the PTBP1...
- This Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, provides $3,018,210 to Baylor College of Medicine under the Aging Research program (CFDA 93.866). The grant funds research to functionally dissect a promising transcriptional regulatory network linked to glutamate excitatory signaling that is downregulated in Alzheimer's disease and enriched for suppressors of neurodegeneration. Researchers will perform genetic manipulations in...
This Project Grant award, with a total funding amount of $878,190.00, was provided by the National Institute on Aging (part of the U.S. Department of Health and Human Services) under the Aging Research federal grant program (CFDA 93.866). The grant is supporting research by the Scripps Research Institute in California to investigate a "druggable mito-nuclear feedback mechanism" that can preserve mitochondrial and synaptic function in aging and age-related dementias like Alzheimer's disease. Key components of the research include single-cell RNA sequencing experiments, studies on the role of ATP synthase in aging, and longitudinal electroencephalogram (EEG) recordings in a mouse model of frontotemporal dementia. The goal is to understand how mitochondrial decline drives neurodegeneration and how a brain-specific mito-nuclear feedback loop could be targeted therapeutically using the drug candidate J147.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $878.2k | 9/8/25 |