This Project Grant award of $3,558,527.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the interaction between sex chromosomes, sex hormones, brain-derived hormones, and brain angiotensin II activation on accelerated brain aging and cognitive decline in Alzheimer's disease. The award was granted to the University of North Texas Health Science Center at Fort Worth and will fund a 5-year study with specific objectives to: 1) Determine the role of...
This Project Grant award of $363,969 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders will support research to characterize the mechanisms by which thyroid hormone regulates HSV-1 latency and reactivation in neurons. The project aims to use computer-guided mutagenesis to generate chimeric viruses and investigate how thyroid hormone binding and neuronal excitability impact...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $2,273,637 Project Grant to The Johns Hopkins University to conduct a comprehensive study of plasma and brain lipidomics (lipid profiling) and their associations with Alzheimer's disease (AD), dementia, and cognitive decline. The study will leverage novel Lipidyzer technology to quantify over 1,500 lipid species in plasma samples from 3,868 participants in the Cardiovascular Health...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $302,960 to Harvard T.H. Chan School of Public Health to conduct research on identifying individuals who would benefit most from intensive blood pressure control for preventing cognitive decline and dementia, as well as those at risk of serious adverse events. The research will utilize advanced statistical methods and pooled data from multiple large-scale randomized trials to detect...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will provide $622,000 to the University of Maryland, Baltimore to conduct research on the role of mitochondrial complex I deficiency in Alzheimer's disease and dementia. The primary goals are to: 1) Determine the effects of complex I deficiency on humanized amyloid-beta proteinopathy, and 2) Assess the susceptibility of complex I-deficient mice to Alzheimer's disease and dementia. The research will utilize...
This Project Grant award for $466,125, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to analyze the effects of Alzheimer's disease on subcellular transcriptome dynamics and mitonuclear coordination in neuronal soma and projections. The research, conducted by Harvard Medical School, will use a novel technique called Subcellular Timelapse-Seq (STL-Seq) to simultaneously quantify the kinetic rates of transcription, nuclear export, ribosome...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) provides $349,605.00 to Stress Therapeutics, Inc. to advance the development of a novel therapeutic candidate for the long-term management of chronic hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis. The project aims to optimize a lead compound that can effectively reduce HPA hyperactivity, which is believed to be a key pathogenic driver of Alzheimer's disease and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a $2,466,305 study to investigate the association between hypertension, hypertension treatment targets, and the risk of Alzheimer's disease and related dementias (ADRD) among a nationally representative sample of 1.4M U.S. veterans. The study aims to: 1) estimate the association between hypertension and ADRD risk, overall and within subgroups defined by race/ethnicity, region, and...
This $2,365,042 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to conduct research on the biological underpinnings of Alzheimer's disease and related dementias (ADRD). The research aims to better characterize the interplay between biological markers of neurodegeneration, vascular, nutritional, and inflammatory systems, and their interface with social and economic factors, by leveraging cross-national comparisons...
This Project Grant award of $372,690 from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to discover the heterogeneous causal pathophysiology of Alzheimer's disease (AD). The project will develop new statistical methods to uncover how amyloid-beta, tau accumulation, and cognition are causally related in different AD subpopulations. The goal is to reveal optimal treatment windows and target groups for therapies that reduce amyloid-beta or...