This $342,934.65 project grant from the Department of Health and Human Services National Institutes of Health National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research into acyl chain remodeling and regional lipid dysregulation in Alzheimer's disease. The Trustees of Columbia University in the City of New York, doing business as Health Sciences Division, will analyze lipid composition in brain regions susceptible to Alzheimer's disease, such as the...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Weill Medical College of Cornell University provides $466,125 in funding from May 2024 to April 2026 to investigate the effects of Alzheimer's disease and related dementias on lipid metabolism and signaling in astrocytes. The study aims to characterize spatiotemporal changes in astrocyte lipids during aging and disease, and determine how these lipid alterations are regulated and may...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $805,738 to the Battelle Memorial Institute's Pacific Northwest National Laboratory to conduct research on the impact of brain lipoprotein structure and composition on amyloid beta metabolism and Alzheimer's disease. The key objectives are to: 1) Assess how APOE isoforms affect brain lipoprotein distribution, composition, and ability to bind amyloid beta, and 2) Determine the...
This $795,542 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at the University of California, Davis to identify pathways involving lipid mediators that promote neuronal survival and repair in Alzheimer's disease (AD). The central hypothesis is that neuronal loss in AD is caused by deficits in the supply of free pro-repair lipid mediators from brain-esterified lipid pools. The research will use tracer studies to understand...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund the development of a high-content screening pipeline to identify small molecule therapeutics that can reduce aberrant lipid accumulation in ApoE4-expressing oligodendrocytes, a key pathological feature of Alzheimer's disease. The $473,216 award, effective September 25, 2024 through August 31, 2025, will support two aims: (1) a targeted screen of ~2,500 lipid-modifying compounds and (2) an...
This federal Project Grant award, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), will support research to map the brain's lipid architecture in aging, Lewy body dementia (LBD), and Parkinson's disease. The $400,707 award to the University of Florida will be used to generate a spatial atlas of the lipidome to identify lipid markers of disease progression, as well as assess lipid alterations resulting from an investigational mRNA-based immunomodulatory approach....
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,340,036.00 to The Johns Hopkins University to develop statistical methods for characterizing patients who highly benefit across multiple clinical outcomes from treatments for Alzheimer's disease and related dementias (ADRD).
The project aims to: 1) Develop methods to accurately identify patients who highly benefit on multiple outcomes from ADRD treatments in randomized trials; 2)...
The Johns Hopkins University was awarded a $2,399,582 Project Grant from the National Institute on Aging (CFDA 93.866 Aging Research) to study extracellular vesicles derived from the brain as potential biomarkers for Alzheimer's disease. The 3-year grant, which begins on September 1, 2023, aims to identify specific cell surface markers and molecular signatures on brain-derived extracellular vesicles that could be used for early disease detection, monitoring, and understanding Alzheimer's...
This $866,723 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to The Johns Hopkins University supports research to integrate high-field post-mortem MRI imaging, histological analysis, and spatial transcriptomic profiling of the entorhinal cortex to better understand the molecular and pathological changes underlying Alzheimer's disease progression. The key objectives are to establish protocols for integrating MRI markers with histological tau pathology,...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,380,018 to the Regents of the University of Michigan to conduct research on the impact of type 2 diabetes and prediabetes on cognitive decline and Alzheimer's disease risk over the life course. The research team will quantify how cumulative hyperglycemia and diabetes management affect cognitive trajectories and Alzheimer's disease risk, and identify potential mechanisms linking...