This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $302,960 to Harvard T.H. Chan School of Public Health to conduct research on identifying individuals who would benefit most from intensive blood pressure control for preventing cognitive decline and dementia, as well as those at risk of serious adverse events. The research will utilize advanced statistical methods and pooled data from multiple large-scale randomized trials to detect...
This Project Grant award from the National Institute on Aging (NIA), under CFDA 93.866 Aging Research, provides $715,801 to Duke University to investigate the causal role of blood-brain barrier dysfunction and neuroinflammation in exacerbating postoperative delirium and subsequent onset of Alzheimer's disease and related dementias in aging and hypertension. The overarching goal is to elucidate how hypertension primes the neurovascular unit and worsens delirium-like behavior after orthopedic...
This $997,008 Project Grant award from the Department of the Army Medical Command under the Military Medical Research and Development program (CFDA 12.420) supports a 3-year research project by the Northern California Institute for Research and Education, Inc. (NCIRE) to investigate risk and resilience factors for Alzheimer's disease and related dementias (ADRD) among American Indian and Alaskan Native veterans. The research aims to inform prevention strategies for this population. NCIRE is a...
This Project Grant award, valued at $2,380,018.00, was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to the Regents of the University of Michigan. The overarching goal is to investigate the influence of cumulative hyperglycemia, type 2 diabetes management, and vascular risk factors on cognitive decline and Alzheimer's disease and related dementias (ADRD) risk. The research team will leverage pooled cohort studies and individual participant data meta-analysis to...
This Project Grant awarded by the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), will fund a study at Tulane University to investigate the relationship between genetic predisposition to hypertension and midlife cognitive function, as well as its potential predictive value when combined with life course modifiable risk factors. The total award is $152,957 and will run from July 15, 2025 to March 31, 2030. The study aims to leverage data from...
This $334,788 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the impact of recent revisions to the Medicare home health payment system (Patient-Driven Groupings Model or PDGM) on access, care delivery, and outcomes for community-living Medicare beneficiaries with Alzheimer's disease and related dementias (ADRD). The 2-year study, starting September 1, 2023, will leverage Medicare claims, home health assessment, and agency data to:...
This Project Grant award of $2,557,260.00 from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) will support a longitudinal study to investigate the transition from midlife to early late-life and the development of early clinical Alzheimer's disease and related dementias (AD/ADRD) among diverse populations. The study, led by the University of California, San Francisco, will conduct cognitive assessments and AD/ADRD adjudication on participants in the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will investigate the impact of Historically Black Colleges and Universities (HBCUs) on late-life cognition and Alzheimer's disease and related dementias (ADRD) outcomes among Black adults. The $520,040.19 award, effective September 1, 2024 through May 31, 2027, will leverage three large national panel datasets to evaluate the causal effects of HBCU attendance and proximity, as well as state/federal...
This $3,109,079 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the University of California, Riverside to investigate the role of traumatic brain injury (TBI) across the lifespan in the development of Alzheimer's disease and related dementias (ADRD). The project will use a closed head injury (CHI) TBI mouse model to examine how ADRD risk factors, such as the APOE4 gene and amyloid-beta, interact with TBI at different life stages...
This $2,365,042 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to conduct research on the biological underpinnings of Alzheimer's disease and related dementias (ADRD). The research aims to better characterize the interplay between biological markers of neurodegeneration, vascular, nutritional, and inflammatory systems, and their interface with social and economic factors, by leveraging cross-national comparisons...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a $2,466,305 study to investigate the association between hypertension, hypertension treatment targets, and the risk of Alzheimer's disease and related dementias (ADRD) among a nationally representative sample of 1.4M U.S. veterans. The study aims to: 1) estimate the association between hypertension and ADRD risk, overall and within subgroups defined by race/ethnicity, region, and military-related exposures like traumatic brain injury and PTSD; 2) assess if military-related exposures modify the hypertension-ADRD relationship; and 3) use a regression discontinuity design to estimate the causal effects of different hypertension treatment targets on ADRD risk, including quantifying the potential reduction in ADRD cases at different treatment targets. The award will be provided to the University of California, San Francisco, which has extensive expertise in federal biomedical research grants and contracts.