This Project Grant award of $791,086 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop computational models that can predict the presence of non-Alzheimer's disease neuropathological changes (non-ADNC), such as Lewy body disease, TDP-43 proteinopathy, and cerebral amyloid angiopathy, in individuals with Alzheimer's disease neuropathological changes. The project will leverage autopsy-confirmed datasets, multimodal neuroimaging, and clinical data to build these...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,281,385 to the University of California, San Diego (UCSD) to examine the role of specific phenotypes, such as sex/gender, APOE4 status, and polygenic hazard scores, on response to drug or lifestyle interventions in existing Alzheimer's disease clinical trial datasets. The project aims to leverage 30 years of harmonized data from 14,602 participants across multiple clinical trials to...
This federal Project Grant award, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), aims to develop and apply advanced statistical methods to improve scientific inferences in Alzheimer's disease (AD) research. The key products and services to be delivered through this $455,274 award made to The Johns Hopkins University include: Developing efficient and statistically proper methods to better model, estimate, and predict the risk of AD incidence...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $4,276,054 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the selective vulnerability of genes, cells, and neural networks in mouse tauopathy models of Alzheimer's disease (AD). The project aims to develop quantitative mathematical models to test hypotheses regarding the selective vulnerability of certain brain regions and cell types to the...
This Project Grant award, valued at $802,034 and funded by the National Institute on Aging's Aging Research program (CFDA 93.866), aims to develop a comprehensive "multimodal, multiscale and multistage systems biology (M3SB) infrastructure" to advance precision medicine for Alzheimer's disease (AD) and longevity research. The key objectives are to: 1) conduct multi-omics analyses to identify bioage-modifying targets and repurposable medicines for AD and related dementias; 2) build...
This $2,332,368 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports a longitudinal, multimodal neuroimaging study to elucidate the role of neuronal dysfunction and hyperexcitability in the early biological progression of Alzheimer's disease. The primary objectives are to: 1) Identify the earliest manifestations of neural circuit hyperexcitability that predict accumulation of regional tau pathology in Alzheimer's disease preclinical stages, and 2)...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $2,251,070 to the University of California Irvine through July 2025. The grant supports research to develop new statistical methodologies for analyzing Alzheimer's disease data from longitudinal cohort studies. Key deliverables include methods for assessing prediction precision for recurrent event survival data using time-dependent ROC and C-index...
This Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $137,895 to The Regents of the University of California, Berkeley to investigate the network drivers of regional vulnerability to early Alzheimer's disease pathology. The project will use positron emission tomography (PET) imaging and resting-state functional MRI to examine how functional brain network connectivity is associated with Alzheimer's disease risk, longitudinal pathology...
This $301,417 federal Project Grant award, provided by the National Institute on Aging under CFDA 93.866 Aging Research, aims to develop innovative analytical methods and software tools for integrating and synthesizing data from Alzheimer's disease and related dementias (AD/ADRD) research studies. The key objectives are to: 1) Create new approaches for modeling and addressing inconsistencies in the evidence from network meta-analyses of AD/ADRD interventions, and 2) Develop novel network...
This $2,557,260 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will fund a study to investigate the early transition to Alzheimer's disease and related dementias (ADRD) among Black and White adults in their 60s. The study, led by the University of California, San Francisco (UCSF), will leverage the ongoing Coronary Artery Risk Development in Young Adults (CARDIA) study to assess cognitive function, neurodegeneration, vascular health, and social determinants...