The National Institute on Aging (NIA) awarded a $105,144 Project Grant under the Aging Research (CFDA 93.866) program to The Medical University of South Carolina (MUSC) on July 17, 2025. The grant supports research to investigate the role of ceramide-induced mitophagy, the recycling of damaged mitochondria, as a potential therapeutic strategy for Alzheimer's disease (AD). The research aims to utilize genetic ablation and a novel ceramide analog, LCL768, to understand the underlying mechanisms of...
This federal Project Grant award, valued at $436,150.00 and provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports research to investigate the role of the NEDD4L E3 ubiquitin ligase in regulating mitochondrial function and its potential contribution to Alzheimer's disease pathogenesis. The grant aims to employ mouse models to determine how the two major NEDD4L isoforms differentially impact mitochondrial function, and to assess the effects of...
The National Institute on Aging (NIA) awarded a $125,896 Project Grant under the Aging Research program (CFDA 93.866) to The Washington University in St. Louis to conduct research on Alzheimer's disease (AD) risk and resilience pathways. The project aims to perform deep molecular characterization of AD genetic risk factors and protective mechanisms using state-of-the-art single-cell multi-omic analyses of healthy and AD human brain tissue, as well as transgenic AD mouse models. Key objectives...
This $6,226,692 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program supports research examining the role of neuronal hyperexcitability and proteostasis in the progression of Alzheimer's disease (AD). The study aims to use a mouse model to investigate how modifications in brain activity, specifically in the locus coeruleus (LC) and hippocampus (HPC), can lead to the pathological hallmarks of AD. Key objectives include tracking early...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) aims to advance understanding of inhibitory interneuron dysfunction and its contribution to neural circuit dysregulation in Alzheimer's disease (AD) and related dementias. The $338,527 award, effective August 15, 2024 through May 31, 2029, will support the following key activities: Identifying disrupted interneuron gene expression patterns in post-mortem AD brain samples using spatial transcriptomic...
This $2,365,042 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to conduct research on the biological underpinnings of Alzheimer's disease and related dementias (ADRD). The research aims to better characterize the interplay between biological markers of neurodegeneration, vascular, nutritional, and inflammatory systems, and their interface with social and economic factors, by leveraging cross-national comparisons...
This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $660,402 to the University of Maryland, Baltimore (UMB) to study the role of autophagy, a cellular process that recycles damaged components, in regulating lipid metabolism and inflammation in microglia during brain aging and neurodegenerative diseases like Alzheimer's disease (AD). The research aims to determine how microglial lipid phagocytosis inhibits autophagy, leading to the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,845,311 to the University of California, San Diego (UCSD) to investigate early determinants of Alzheimer's disease (AD) using age-equivalent neurons derived from mild cognitive impairment (MCI) patients. The overarching goal is to better understand the early trajectory of MCI and AD pathogenesis by leveraging patient-derived induced neurons (iNs) that capture genetic risk factors and...
This Project Grant award of $308,000 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the mechanisms by which amyloid-beta 42 (Aβ42) interferes with mitochondrial liquid-liquid phase separation, causing morphological and functional mitochondrial defects in Alzheimer's disease. The two specific aims are: 1) to investigate the impact of Aβ42 on mitochondrial ribonucleoprotein granule dynamics, and 2) to use optogenetic control of Aβ42 and mitochondrial...
This federal Project Grant award, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), aims to understand the mechanisms responsible for autophagy defects in neurons affected by Alzheimer's disease (AD). The $749,030 grant, awarded on December 15, 2024, will support experiments with a transgenic AD mouse model to evaluate the effects of various pharmacological interventions targeting calcium signaling and autophagy. The goal is to validate novel...