Project Grant K01DK141911

This $143,874 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to identify mechanisms by which resistance exercise training (RET) enhances muscle insulin sensitivity. The award will support research at the Mayo Clinic to: 1) measure synthesis rates of individual muscle proteins in response to RET using stable isotope labeling in human myotubes; 2) determine if glycolytic and contractile protein deacetylation or phosphorylation is associated with improved insulin sensitivity after 2 weeks of RET in sedentary individuals; and 3) investigate the role of the PGC-1α4 isoform in RET-induced muscle protein synthesis. The research seeks to unveil new mechanistic targets for understanding how RET influences metabolism, with the goal of improving treatment strategies for type 2 diabetes. This grant, awarded on January 8, 2025, will run through December 31, 2029.