This Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to understand the mechanisms by which glucocorticoid drugs induce insulin resistance and metabolic dysfunction in skeletal muscle. The $112,500 award, with a project period from September 1, 2024 to August 31, 2025, will be conducted by the Pennington Biomedical Research...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) provides $1,041,906 to the Regents of the University of Michigan to investigate the role and mechanism of the protein UNC119B in regulating glucose homeostasis and its potential as a target for treating type II diabetes. The research aims to: Determine the importance of UNC119B in glucose storage tissues for maintaining glucose homeostasis. Evaluate whether improving insulin...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is focused on enhancing the metabolic maturity of human pluripotent stem cell-derived islet organoids for improved transplantation outcomes in type 1 diabetes. The $681,562 award, granted on July 21, 2025, will support research at the University of Michigan to investigate pharmacological and 3D...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,600,000 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Icahn School of Medicine at Mount Sinai. The project, titled "Decoding Endocrine and Paracrine Communication Through Mammokines," aims to discover new signaling molecules from the mammary gland that influence metabolic function and the progression of obesity and type 2...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $108,000 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Regents of the University of Michigan. The grant, titled "MICHIGAN SUMMER UNDERGRADUATE RESEARCH EXPERIENCE: DIABETES & METABOLIC DISEASES", will provide a 5-year summer research experience for 14 undergraduate students per year to instill an appreciation and passion for...
This $391,250 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support research on extracellular vesicle-dependent RNA signaling in metabolism. The project aims to identify key proteins involved in the delivery of adipose microRNAs into liver cells via extracellular vesicles, and to determine if this RNA delivery mechanism is necessary for...
This Project Grant award of $400,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to explore the role of insulin resistance in the development of renal disease during prepubertal childhood obesity. The research aims to investigate how insulin resistance alters glucose transport and energy metabolism in renal proximal tubules, potentially leading to...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is dedicated to the development and optimization of non-peptide ligands designed to activate insulin receptors. The $772,383 research project aims to transform approaches to glycemic control in the management of diabetes by uncovering a new generation of receptor modulators that could...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) provides $174,368 to the Regents of the University of Michigan to support a research project focused on understanding the role of the LRRK2 kinase in pancreatic beta cell responses to inflammatory damage. The goal is to gain insights into the molecular mechanisms that govern beta cell survival under inflammatory conditions, which could inform new therapeutic approaches for treating...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $194,966 to The Trustees of Columbia University in the City of New York to conduct research on insulin resistance and metabolic dysfunction. The goal of the research is to demonstrate the existence of selective insulin resistance in humans, where high insulin levels continue to...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), funded under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop a noninvasive method for earlier detection of skeletal muscle insulin resistance and dysfunction as a precursor to type 2 diabetes. The $389,621 award will support prospective ultrasound imaging of skeletal muscles, concurrent laboratory testing, and analysis of muscle biopsies to clarify the association between increased muscle echo intensity and the structural, functional, and histopathological changes that precede clinically apparent metabolic dysfunction. The goal is to enable earlier intervention and treatment for metabolic and muscle dysfunction before the onset of type 2 diabetes complications. The award was made to the Regents of the University of Michigan, a leading U.S. research university, and will run from August 2024 to July 2025.