This $659,199 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to investigate a novel pathway by which the protein growth differentiation factor 15 (GDF15) produced in liver hepatocytes can improve obesity-associated insulin resistance independently of changes in body weight or the GFRAL receptor.
The research will characterize the structural basis and functional consequences of GDF15's interaction with the matrix metalloproteinase-14 (MMP14) protein, as well as the molecular signaling and physiological effects of several GDF15 mutants. This work seeks to enhance understanding of GDF15 as a potential therapeutic target for obesity and type 2 diabetes. The project will be conducted by the University of Pittsburgh, a major recipient of NIH research grants, over the award period from February 2025 to January 2029.
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