The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,439,769 project grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Southern California. This 5-year study, titled "PFAS Exposure and Diabetic Kidney Disease in Youth with Type 2 Diabetes: A Multi-Omic Approach for Prevention and Treatment," aims to investigate the link between exposure to per- and polyfluoroalkyl substances...
This $820,119 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research focused on elucidating the mechanobiological functions of novel cytoskeletal structures in podocytes to reveal new therapeutic opportunities for kidney glomerular diseases. The primary research aims to better understand the mechanisms underlying podocyte homeostasis,...
This $400,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to understand the earliest events in podocyte injury in collagen IV nephropathies. The goal is to investigate how processing of mutant collagen IV proteins injures podocytes at early stages, leading to chronic kidney disease and renal failure. The research uses...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $436,277 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Delaware. The grant titled "NEPHROGENESIS ON A CHIP: AN SIMPLE MODULAR PLATFORM TO SPATIALLY PATTERN EXTRACELLULAR MATRIX, STROMAL CELLS, AND SOLUBLE FACTORS" aims to develop an easy-to-use 3D in vitro model of the developing nephron that allows spatial patterning...
This $830,500 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research by Georgetown University to investigate the role of glycosphingolipids in kidney disease associated with diabetes and obesity. The research aims to determine if inhibiting glucosylceramide synthesis can prevent kidney disease progression, improve mitochondrial function, and reduce...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $168,886.00 to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research titled "Elucidating the Role of NAD+ and PARylation in Nephron Endowment." The award aims to study how maternal availability of nicotinamide adenine dinucleotide...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $659,199 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Pittsburgh. The grant, awarded on February 25, 2025, supports research to investigate a novel pathway by which hepatocyte-derived growth differentiation factor 15 (GDF15) can improve obesity-associated insulin resistance independent of changes in body weight and the GDF15...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will provide $596,345 to Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the molecular mechanisms underlying diabetic renal hypertrophy and its impact on acute kidney injury (AKI) susceptibility and severity in diabetes. The key objectives are to: (1) determine...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $695,295.00 to study the developmental trajectories of reinforcer pathology and childhood obesity. The project will assess how the reinforcing value of food and physical activity, as well as delay discounting, change throughout childhood and adolescence, and how these...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Vanderbilt University a 2-year, $356,625 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The objective is to develop a multi-tissue 13C metabolic flux analysis (MFA) platform to simultaneously assess kidney metabolism and its relationship with liver and heart metabolism in live animal models. Key products and services to be delivered include: 1)...