Project Grant R00DK125722

This Project Grant award of $110,726.00 from the Department of Health and Human Services National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) aims to utilize data from the Molecular Transducers of Physical Activity Consortium (MoTrPAC) to characterize the molecular aging of white adipose tissue and the potential impact of endurance exercise training, with a focus on sex-specific differences. The research project led by the Pacific Northwest National...

The University of Arizona was awarded a $625,316 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to investigate the role of RNA methylation and translational regulation in the oxidative stress response of heart failure. The research aims to elucidate how the YTHDF2 protein binds to methylated NRF2 mRNA to selectively induce its translation under oxidative stress, a process that may be impaired in end-stage heart failure. The...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $199,258 to the Oklahoma Medical Research Foundation (OMRF) to determine the influence of metformin treatment on mitochondrial calcium flux during aerobic exercise training in healthy, aging rats. The key objectives are to: 1) assess how metformin treatment alters mitochondrial calcium kinetics during aerobic exercise training, and 2) evaluate if metformin treatment during training affects the...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $386,900.00 to the University of Texas Health Science Center at Houston (UTHealth) to study the role of the circadian clock and retinoid acid receptor-related orphan receptor (ROR) proteins in regulating metabolic function and healthy aging. The key objectives are to: 1) Evaluate the impact of ROR proteins on healthspan and lifespan using mice with skeletal muscle-specific ROR knockout, 2)...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $1,345,188.00 to the University of California, San Diego (UCSD) to elucidate the mechanisms by which the eukaryotic initiation factor 5A (EIF5A) influences mitochondrial function. The key objectives of this research are to investigate how EIF5A depletion leads to ribosome stalling on mitochondrial proteins during...

This Project Grant award of $473,096 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research at the University of Utah to understand the role of lactate oxidation in the mitochondria of cardiomyocytes and its impact on cardiac function in heart failure. The key objectives are to: 1) Quantify direct versus indirect mitochondrial lactate oxidation in healthy and failing hearts; 2) Determine if mitochondrial localized MCT1 is necessary...

This $120,573 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research by Dr. Matthew D. Campbell at the University of Washington to investigate dysfunctional redox-sensitive signaling mechanisms in aged skeletal muscle that impact metabolic function following exercise. The research aims to: 1) establish how dysfunctional redox signaling alters substrate utilization after exercise, 2) determine the impact on beta-oxidation and TCA cycle...

The National Institutes of Health's National Center for Advancing Translational Sciences (NCATS) awarded a $145,636 project grant (CFDA 93.350) to Beth Israel Deaconess Medical Center, Inc. (Bidmc) to evaluate the relationship between thyroid hormone levels and brown adipose tissue activity, transcriptome, and cellular composition in adult humans. The study aims to better understand the interaction between the thyroid axis and brown adipose tissue in the process of thermogenesis and energy...

This Project Grant award of $604,853 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will fund research at Rockefeller University to elucidate the genetic determinants of human brown adipose tissue (BAT) function. The goal is to develop a better understanding of how BAT, which can protect against obesity and associated metabolic diseases, is regulated in humans. The research will leverage...

This federal Project Grant award of $154,000 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research to investigate the role of long non-coding RNA (lncRNA) in regulating cardiac mitochondrial function, with a focus on the impact of ketosis and intermittent fasting in heart failure. Key activities include studying the upregulation of lncRNA MALAT1 under ketotic conditions and...