This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), funded under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop a noninvasive method for earlier detection of skeletal muscle insulin resistance and dysfunction as a precursor to type 2 diabetes. The $389,621 award will support prospective ultrasound imaging of skeletal muscles, concurrent laboratory testing, and analysis of muscle...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $143,874 to the Mayo Clinic in Rochester, Minnesota to conduct research aimed at understanding the mechanisms by which resistance exercise training improves muscle insulin sensitivity. The overarching goal is to identify how resistance exercise impacts protein synthesis, post-translational modifications,...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,600,000 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Icahn School of Medicine at Mount Sinai. The project, titled "Decoding Endocrine and Paracrine Communication Through Mammokines," aims to discover new signaling molecules from the mammary gland that influence metabolic function and the progression of obesity and type 2...
This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research), supports research to explore the role of activin type II receptor (ACTRII) signaling in muscle hypertrophy, obesity, and weight loss. The $2,060,811 award, effective from December 1, 2024 to November 30, 2029, will be conducted by the Trustees of the University of Pennsylvania. The research aims to...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $124,536 to investigate the role of branched-chain amino acid (BCAA) metabolism in regulating adiposity during systemic hypoxia. The research aims to elucidate the mechanisms underlying the reprogramming of BCAA metabolism in adipose tissue under oxygen deprivation, and to determine the...
The National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) awarded a $355,111 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Pennington Biomedical Research Center in Baton Rouge, Louisiana. The 5-year grant, running from August 1, 2024 to June 30, 2029, will fund research to better define the mechanisms of the glycophagy shunt and its role in cellular metabolism. The research aims to enhance understanding of glycogen metabolism,...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is dedicated to the development and optimization of non-peptide ligands designed to activate insulin receptors. The $772,383 research project aims to transform approaches to glycemic control in the management of diabetes by uncovering a new generation of receptor modulators that could...
This federal Project Grant award of $105,398.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The project aims to assess the persistent effects of dietary protein restriction on protein motivation and underlying physiology in animals. Specifically, the research will examine measures of protein preference, economic "demand", FGF21 production, and...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) provides $106,188 to Vanderbilt University to conduct research on the impact of morning insulin delivery on hepatic glucose metabolism later in the day. The research, which will use complex metabolic clamping experiments in a conscious dog model, aims to elucidate the mechanisms by which morning hyperinsulinemia enhances the liver's subsequent glucose response. Specifically, the study...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $938,470 to the University of Massachusetts Medical School to investigate a novel adipokine that may resolve non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in mouse models. The award period runs from September 1, 2024 to June 30, 2028. The research aims...