This R01 project grant award, totaling $530,890.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research to identify tissue- and disease-specific processes underlying type 1 diabetes (T1D) susceptibility by comparing autoimmune T cell development and function in mouse models expressing T1D-associated major histocompatibility complex...
This $4,087,560 Project Grant award was issued on July 1, 2024 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The project aims to develop a comprehensive database of functionally important RNA modifications in selected human tissues to investigate their role in the development of type 2 diabetes and obesity.
Key activities include: 1) mapping mRNA and...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $949,056 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Northwestern University. The grant funding will support research to investigate the functional roles of the DDX41 gene in the homeostasis of G-quadruplexes, which are unique DNA structures, and their impact on erythropoiesis (red blood cell production) and the development of myelodysplastic...
This $248,915 Project Grant award was issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) with a performance period of February 1, 2025 to January 31, 2028. The award titled "UNRAVELLING THE ROLE OF EPIGENETICS AND CYTOKINES IN TYPE 2 DIABETES AMONG AFRICAN-ANCESTRY POPULATIONS" will support research conducted by the University of Maryland, Baltimore (UMB)...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to elucidate the role of the XBP1 transcription factor in regulating pancreatic beta cell function and survival under metabolic stress. The $444,867 award, to be completed by August 31, 2025, will utilize a novel mouse model developed by the Beckman Research Institute of the City...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $171,134 to investigate how pro-inflammatory cytokines impact the structure and function of the Golgi apparatus in pancreatic beta cells. The research aims to understand the role of the GRASP55 protein in mediating cytokine-induced Golgi remodeling and its implications for...
This $724,053 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research at the Joslin Diabetes Center focused on understanding the effects of glucose toxicity on insulin biosynthesis in beta cells. The research aims to investigate how chronic exposure to high glucose levels dysregulates the translation of insulin mRNA and other secretory...
This $619,409 Project Grant award was issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The primary objective is to better understand the role of primary cilia in regulating pancreatic beta cell function and metabolism, with a focus on how compartmentalized glucose metabolism in the cilia affects beta cell glucose sensing and insulin secretion. The principal...
This federal Project Grant award for $506,546.00, granted by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to define the molecular determinants of inflammatory memory in the pancreas. The award, effective July 1, 2024 through May 31, 2029, is provided to Weill Medical College of Cornell University to leverage lineage-traced mouse models to: 1)...
This $148,568 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) aims to advance cell-based therapies for type 1 diabetes. The key objectives are to: 1) Optimize a low-intensity conditioning protocol to induce mixed hematopoietic chimerism and tolerance for allogeneic islet transplants, and 2) Evaluate the immunogenicity of mouse pluripotent stem...