Project Grant R01DK136700

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $562,214 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Regents of the University of Michigan. The grant will fund a 4-year research project to investigate the mechanisms by which exercise enhances subsequent insulin-stimulated glucose uptake in skeletal muscle, with the goal of advancing understanding and potential treatments for type 2 diabetes. Key objectives include identifying Rab proteins that collaborate with the AS160 regulator to facilitate post-exercise glucose uptake, elucidating how exercise alters subcellular GLUT4 localization, and examining estrogen receptor-dependent mechanisms contributing to sex differences in this exercise effect. The University of Copenhagen and University of Missouri System will provide specialized expertise and services via sub-awards to support the research activities.