Project Grant RF1MH139576
- This $3.06 million Project Grant, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, funds a four-year research initiative (August 2025–July 2029) conducted by the University of Wisconsin–Madison. The award supports the development and characterization of a nonhuman primate model of synucleinopathy to investigate the relationship between alpha-synuclein (αSyn)...
- This $2,044,038 federal Project Grant award, funded by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research into the mechanisms driving anxiety in Alzheimer's disease (AD). The project, led by New York University School of Medicine, aims to investigate the role of the thalamo-hippocampal-prefrontal circuit in AD-related anxiety. The research will use mouse models of AD to elucidate the functional synaptic architecture, in vivo neural activity, and causal impact of...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded University of Massachusetts Medical School a $612,425 Project Grant on March 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct longitudinal neuroimaging research examining visual discrimination and anxiety in children. The research aims to identify early trait-based neural markers associated with anxiety disorder risk by investigating how children with high trait anxiety process...
- UNDERSTAND Project Grant Summary The University of California, San Diego received a $2.12M project grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), awarded August 1, 2026, with a completion date of July 31, 2029. The UNDERSTAND project will develop and evaluate an innovative mobile health system designed to deliver just-in-time adaptive interventions (JITAI) based on Dialectical Behavior Therapy (DBT) principles to young...
- Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital a Project Grant totaling $677,276 on February 15, 2026, under the Aging Research program (CFDA 93.866) to develop and validate positron emission tomography (PET) imaging technology for detecting alpha-synuclein pathology in neurodegenerative diseases. The award, which extends through January 31, 2031, funds research to evaluate the selective PET tracer [11C]SY08 as a diagnostic tool to...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded the University of Pittsburgh a $782,547 Project Grant on August 19, 2025, under the Mental Health Research Grants program (CFDA 93.242) to investigate the role of puberty in corticostriatal circuitry development and avoidance behavior in adolescents with anxiety disorders. The research will extend through July 31, 2030, and focuses on understanding how pubertal hormones impact reward processing and learning...
- The University of Delaware received a $182,436 Project Grant awarded on October 12, 2025, from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). This research initiative examines neural network disturbances underlying the co-occurrence of depression and anxiety in adolescents through advanced neuroimaging analysis. Rather than focusing on isolated brain regions, the project employs a network perspective using graph theory and...
- This Project Grant, awarded June 1, 2026, by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), provides $126,789 in federal funding to The Research Foundation for the State University of New York, operating as Stony Brook University, for basic neuroscience research through December 31, 2029. The award supports fundamental investigation into the role of myocyte...
- Federal Project Grant Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Regents of the University of California, San Francisco a $238,680 Project Grant (CFDA 93.853: Extramural Research Programs in the Neurosciences and Neurological Disorders) on July 15, 2026, with completion targeted for June 30, 2031. The research project, "Dissecting Neural Circuits Regulating Sleep Fragmentation in Parkinson's Disease," investigates the neural mechanisms...
- This $576,337 National Institute of Mental Health project grant funds research at Stanford University to evaluate a biomarker-guided intervention approach for anhedonia in treatment-resistant depression. The grant supports a clinical trial targeting D3 receptor agonism with pramipexole to determine its effects on ventral striatum brain activation as measured by functional neuroimaging. The study aims to enroll treatment-resistant depression patients with prominent anhedonia to evaluate whether...
ANXIETY IN PARKINSON'S DISEASE: USING FMRI TO EVALUATE AMYGDALA NETWORKS IN THE ON AND OFF DOPAMINE STATE - PROJECT SUMMARY ANXIETY IS A TOP UNMET NEED IN PEOPLE WITH PARKINSON'S DISEASE (PD) ASSOCIATED WITH HIGH LEVELS OF DISTRESS, CAREGIVER BURDEN, LOWER QUALITY OF LIFE, AND DISRUPTION OF USUAL ACTIVITIES. DIAGNOSIS AND TREATMENT OF ANXIETY IN PD IS COMPLICATED DUE TO ITS ASSOCIATION WITH DOPAMINE FLUCTUATIONS, COMORBIDITY WITH DEPRESSION, AND LACK OF EVIDENCE-BASED TREATMENTS. THE RESULT IS THAT ANXIETY OFTEN GOES UNDIAGNOSED AND UNTREATED, OR IS TREATED WITH INAPPROPRIATE, POTENTIALLY DANGEROUS MEDICATIONS. THE GOAL OF THE PROPOSED STUDY IS TO UNDERSTAND THE BRAIN NETWORKS INVOLVED IN ANXIETY, TEST HOW THEY ARE AFFECTED BY DOPAMINE FLUCTUATIONS RESULTING FROM THE TREATMENT OF PD MOTOR SYMPTOMS WITH DOPAMINERGIC AGENTS, AND DETERMINE IF ANXIETY AND DEPRESSION HAVE DISSOCIABLE NEURAL NETWORKS IN PD. THE STUDY AIMS TO ACHIEVE THESE GOALS USING DETAILED PSYCHIATRIC AND NEUROPSYCHOLOGICAL ASSESSMENTS AS WELL AS HIGH-RESOLUTION FUNCTIONAL MAGNETIC RESONANCE IMAGING (FMRI) METHODS IN PD PATIENTS WITH ANXIETY, PD PATIENTS WITHOUT ANXIETY OR OTHER PSYCHIATRIC CONDITIONS, AND HEALTHY CONTROLS. A TARGETED FMRI ACTIVATION TASK WILL BE EMPLOYED DESIGNED TO TAX MEDIAL TEMPORAL LOBE NETWORKS INCLUDING THE AMYGDALA. HIGH-RESOLUTION RESTING- STATE FMRI WILL BE USED TO ASSESS CONNECTIVITY BETWEEN AMYGDALA AND LOCAL AND WHOLE BRAIN CORTICAL NETWORKS. COMPLETING THESE ASSESSMENTS BOTH DURING THE ON AND OFF-DOPAMINE MEDICATION STATE WILL FURTHER HELP DETERMINE WHETHER ANXIETY AND UNDERLYING AMYGDALA NETWORKS ARE ALTERED BY FLUCTUATIONS IN DOPAMINE LEVELS. TOGETHER THE PROPOSED STUDIES WILL PROVIDE KEY INSIGHTS INTO THE ROLE OF THE AMYGDALA, ITS SUBREGIONS, AND ITS NETWORKS IN THE EXPERIENCE OF ANXIETY IN PD. THE RESULTS WILL DETERMINE WHETHER ANXIETY AND DEPRESSION ARE DISSOCIABLE CONDITIONS IN PD SUBSERVED BY DISTINCT AMYGDALA SUBREGIONS AND NETWORKS IN PD. FINALLY, THIS WORK COULD ADDITIONALLY PROVIDE A TARGET FOR THE DEVELOPMENT OF NEW THERAPEUTIC INTERVENTIONS FOR ANXIETY IN PD.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.7m | 4/28/26 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
SUB00005265S | The Johns Hopkins University | Project Grant RF1MH139576 | $281.6k | 7/28/26 |