This $6,226,692 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program supports research examining the role of neuronal hyperexcitability and proteostasis in the progression of Alzheimer's disease (AD). The study aims to use a mouse model to investigate how modifications in brain activity, specifically in the locus coeruleus (LC) and hippocampus (HPC), can lead to the pathological hallmarks of AD. Key objectives include tracking early...
This National Institute on Aging (NIA) Project Grant Award under the Aging Research federal grant program (CFDA 93.866) provides $716,919 to the University of Southern California (USC) to conduct research on understanding the neural bases for neuropsychiatric impairments in Alzheimer's disease (AD) models. The project aims to explore the cortical pathological, molecular, cellular, and transcriptional changes associated with the progression of neuropsychiatric symptoms (NPS) in AD, and...
This Project Grant award, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), aims to investigate the mechanisms underlying neuronal hyperexcitability in the entorhinal cortex (EC) of Alzheimer's disease (AD) mouse models. The $1,758,779 award, effective August 1, 2024 through July 31, 2026, will support studies to determine whether hyperexcitability is due to dysfunction of excitatory or inhibitory neurons in the EC. The research will use...
This federal Project Grant award, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), aims to understand the mechanisms responsible for autophagy defects in neurons affected by Alzheimer's disease (AD). The $749,030 grant, awarded on December 15, 2024, will support experiments with a transgenic AD mouse model to evaluate the effects of various pharmacological interventions targeting calcium signaling and autophagy. The goal is to validate novel...
This Project Grant award of $3,929,011, provided by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program, is funding a longitudinal, multimodal neuroimaging study to elucidate the role of neuronal dysfunction and hyperexcitability in the early biological progression of Alzheimer's disease. The study aims to identify the earliest manifestations of neural circuit hyperexcitability that predict the accumulation of tau protein and cognitive deficits in individuals...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $429,000.00 to the University of Texas Health Science Center at Houston (UTHealth) to study the impact of Alzheimer's disease pathogenesis on the activity of corticotropin releasing factor (CRF) neurons and regulation of the hypothalamic-pituitary-adrenal (HPA) axis. The research aims to identify a direct mechanism connecting Alzheimer's disease progression with dysregulation of the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to elucidate the molecular mechanisms underlying the neurodegenerative function of a subset of microglia (the brain's immune cells) in Alzheimer's disease (AD). The $442,357 award, effective December 15, 2024 through November 30, 2029, supports research by the Research Foundation of the City University of New York's Advanced Science Research Center to investigate how cellular stress signaling,...
The National Institute on Aging (NIA), under the Federal Aging Research program (CFDA 93.866), awarded a $245,148 project grant to Eyenexo LLC to develop an automated rodent behavior testing system for non-invasively assessing early-stage Alzheimer's disease (AD). The project aims to develop a behavior biomarker that can differentiate AD from normal aging by studying defensive behaviors triggered by looming stimuli, which are linked to early AD pathology in the midbrain region. The 2-year...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $203,278 to Brandeis University to conduct research on the neurobiological mechanisms underlying daily life activity participation in older adults and its relationship to Alzheimer's disease pathology. The research will use behavioral, psychophysiological, neuroimaging, and naturalistic approaches to understand age-related shifts in motivation and neuromodulation that impact older...
This $107,948 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to enhance understanding of the biological signatures that distinguish subgroups of patients with Alzheimer's disease (AD). The key goals are to: Determine if AD subtypes can be identified solely using magnetic resonance imaging (MRI)-derived features through the application of machine learning algorithms. Integrate epigenetic profiles, including small non-coding RNA expression and DNA...